Hit to leadHit to lead (H2L) also known as lead generation is a stage in early drug discovery where small molecule hits from a high throughput screen (HTS) are evaluated and undergo limited optimization to identify promising lead compounds. These lead compounds undergo more extensive optimization in a subsequent step of drug discovery called lead optimization (LO).
Artificial intelligenceArtificial intelligence (AI) is the intelligence of machines or software, as opposed to the intelligence of human beings or animals. AI applications include advanced web search engines (e.g., Google Search), recommendation systems (used by YouTube, Amazon, and Netflix), understanding human speech (such as Siri and Alexa), self-driving cars (e.g., Waymo), generative or creative tools (ChatGPT and AI art), and competing at the highest level in strategic games (such as chess and Go).
Drug policyA drug policy is the policy regarding the control and regulation of psychoactive substances (commonly referred to as drugs), particularly those that are addictive or cause physical and mental dependence. While drug policies are generally implemented by governments, entities at all levels (from international organisations, national or local government, administrations, or private places) may have specific policies related to drugs.
Drug liberalizationDrug liberalization is a drug policy process of decriminalizing or legalizing the use or sale of prohibited drugs. Variations of drug liberalization include: drug legalization, drug re-legalization and drug decriminalization. Proponents of drug liberalization may favor a regulatory regime for the production, marketing, and distribution of some or all currently illegal drugs in a manner analogous to that for alcohol, caffeine and tobacco.
Prohibition of drugsThe prohibition of drugs through sumptuary legislation or religious law is a common means of attempting to prevent the recreational use of certain intoxicating substances. While some drugs are illegal to possess, many governments regulate the manufacture, distribution, marketing, sale, and use of certain drugs, for instance through a prescription system. For example, amphetamines may be legal to possess if a doctor has prescribed them; otherwise, possession or sale of the drug is typically a criminal offense.
Artificial general intelligenceAn artificial general intelligence (AGI) is a hypothetical type of intelligent agent. If realized, an AGI could learn to accomplish any intellectual task that human beings or animals can perform. Alternatively, AGI has been defined as an autonomous system that surpasses human capabilities in the majority of economically valuable tasks. Creating AGI is a primary goal of some artificial intelligence research and of companies such as OpenAI, DeepMind, and Anthropic. AGI is a common topic in science fiction and futures studies.
Drug testA drug test is a technical analysis of a biological specimen, for example urine, hair, blood, breath, sweat, or oral fluid/saliva—to determine the presence or absence of specified parent drugs or their metabolites. Major applications of drug testing include detection of the presence of performance enhancing steroids in sport, employers and parole/probation officers screening for drugs prohibited by law (such as cocaine, methamphetamine, and heroin) and police officers testing for the presence and concentration of alcohol (ethanol) in the blood commonly referred to as BAC (blood alcohol content).
Applications of artificial intelligenceArtificial intelligence (AI) has been used in applications to alleviate certain problems throughout industry and academia. AI, like electricity or computers, is a general purpose technology that has a multitude of applications. It has been used in fields of language translation, image recognition, credit scoring, e-commerce and other domains. Recommendation system A recommendation system predicts the "rating" or "preference" a user would give to an item.
Zombie processOn Unix and Unix-like computer operating systems, a zombie process or defunct process is a process that has completed execution (via the exit system call) but still has an entry in the process table: it is a process in the "Terminated state". This occurs for the child processes, where the entry is still needed to allow the parent process to read its child's exit status: once the exit status is read via the wait system call, the zombie's entry is removed from the process table and it is said to be "reaped".
Process (computing)In computing, a process is the instance of a computer program that is being executed by one or many threads. There are many different process models, some of which are light weight, but almost all processes (even entire virtual machines) are rooted in an operating system (OS) process which comprises the program code, assigned system resources, physical and logical access permissions, and data structures to initiate, control and coordinate execution activity.
