Peripheral toleranceIn immunology, peripheral tolerance is the second branch of immunological tolerance, after central tolerance. It takes place in the immune periphery (after T and B cells egress from primary lymphoid organs). Its main purpose is to ensure that self-reactive T and B cells which escaped central tolerance do not cause autoimmune disease. Peripheral tolerance prevents immune response to harmless food antigens and allergens, too.
Allele frequencyAllele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage. Specifically, it is the fraction of all chromosomes in the population that carry that allele over the total population or sample size. Microevolution is the change in allele frequencies that occurs over time within a population. Given the following: A particular locus on a chromosome and a given allele at that locus A population of N individuals with ploidy n, i.
Continuously variable transmissionA continuously variable transmission (CVT) is an automatic transmission that can change through a continuous range of gear ratios. This contrasts with other transmissions that provide a limited number of gear ratios in fixed steps. The flexibility of a CVT with suitable control may allow the engine to operate at a constant RPM while the vehicle moves at varying speeds. CVTs are used in cars, tractors, side-by-sides, motor scooters, snowmobiles, bicycles, and earthmoving equipment.
Automatic transmissionAn automatic transmission (sometimes abbreviated AT) is a multi-speed transmission used in motor vehicles that does not require any input from the driver to change forward gears under normal driving conditions. The most common type of automatic transmission is the hydraulic automatic, which uses a planetary gearset, hydraulic controls, and a torque converter. Other types of automatic transmissions include continuously variable transmissions (CVT), automated manual transmissions (AMT), and dual-clutch transmissions (DCT).
Signs and symptoms of HIV/AIDSThe stages of HIV infection are acute infection (also known as primary infection), latency, and AIDS. Acute infection lasts for several weeks and may include symptoms such as fever, swollen lymph nodes, inflammation of the throat, rash, muscle pain, malaise, and mouth and esophageal sores. The latency stage involves few or no symptoms and can last anywhere from two weeks to twenty years or more, depending on the individual. AIDS, the final stage of HIV infection, is defined by low CD4+ T cell counts (fewer than 200 per μL), various opportunistic infections, cancers, and other conditions.
Management of HIV/AIDSThe management of HIV/AIDS normally includes the use of multiple antiretroviral drugs as a strategy to control HIV infection. There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. The use of multiple drugs that act on different viral targets is known as highly active antiretroviral therapy (HAART). HAART decreases the patient's total burden of HIV, maintains function of the immune system, and prevents opportunistic infections that often lead to death.
Percentage pointA percentage point or percent point is the unit for the arithmetic difference between two percentages. For example, moving up from 40 percent to 44 percent is an increase of 4 percentage points (although it is a 10-percent increase in the quantity being measured, if the total amount remains the same). In written text, the unit (the percentage point) is usually either written out, or abbreviated as pp or p.p. to avoid confusion with percentage increase or decrease in the actual quantity.
PercentageIn mathematics, a percentage () is a number or ratio expressed as a fraction of 100. It is often denoted using the percent sign (%), although the abbreviations pct., pct, and sometimes pc are also used. A percentage is a dimensionless number (pure number), primarily used for expressing proportions, but percent is nonetheless a unit of measurement in its orthography and usage. For example, 45% (read as "forty-five per cent") is equal to the fraction 45/100, the ratio 45:55 (or 45:100 when comparing to the total rather than the other portion), or 0.
Antimicrobial resistanceAntimicrobial resistance (AMR) occurs when microbes evolve mechanisms that protect them from the effects of antimicrobials (drugs used to treat infections). All classes of microbes can evolve resistance where the drugs are no longer effective. Fungi evolve antifungal resistance. Viruses evolve antiviral resistance. Protozoa evolve antiprotozoal resistance, and bacteria evolve antibiotic resistance. Together all of these come under the umbrella of antimicrobial resistance.
Automated manual transmissionThe automated manual transmission (AMT) is a type of transmission for motor vehicles. It is essentially a conventional manual transmission equipped with automatic actuation to operate the clutch and/or shift gears. Many early versions of these transmissions that are semi-automatic in operation, such as Autostick, which automatically control only the clutch — often using various forms of clutch actuation, such as electro-mechanical, hydraulic, pneumatic, or vacuum actuation — but still require the driver's manual input and full control to initiate gear changes by hand.
