Publications related to Design, Synthesis and in vitro Controlled Release of New Adamantanodiarylketone Antimycobacterials

Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles

Carrier-mediated drug delivery has emerged as a powerful methodology for the treatment of various pathologies. The therapeutic index of traditional and novel drugs is enhanced via the increase of specificity due to targeting of drugs to a particular tissue ...

EPFL2005

Heterosubstituted or functionalized derivatives of 1- and 2-(trifluoromethyl)naphthalenes emanating from aryne adducts

Frédéric Bailly, Fabrice Cottet

More than two dozen new CF3-substituted naphthalene derivs. were prepd. in an expedient way by employing 3- and 4-(trifluoromethyl)benzyne as the key intermediates. 2- And 4-Chlorobenzotrifluoride were treated with butyllithium and the organometallic speci ...

2005

Scope and limitations of the double [4+3]-cycloadditions of 2-oxyallyl cations to 2,2 '-methylenedifuran and derivatives

Pierre Vogel, Marc-Etienne Schwenter, Kai Torsten Meilert

The reactivity of various 2-oxyallyl cations toward 2,2'-methylenedifuran (1b), 2,2'-(hydroxymethyl)difuran (1c), 2,2'-(trimethylsilylmethylene)difuran (1d), and di(2-furyl)methanone (1e) has been explored. Difuryl derivatives 1c, 1d, and le refused to und ...

2003

Metabolism of atrazine and derivatives in vetiver plants

Jean-Paul Schwitzguebel, Sylvie Vullioud-Marcacci

Metabolism of atrazine and derivatives in vetiver plants ...

2003

Asymmetric synthesis of 1-aminopentadecane-3,5,7,9,11,13,15-heptols and of 1,15-diaminopentadecane-3,5,7,9,11,13-hexols and derivatives

Pierre Vogel, Sandrine Gerber

Starting from 2,2'-methylenedifuran, enantiomerically enriched (98%) (3R,5S,7R,9S,11R,13R)- and (3R,5S,7S,9R,11R,13R)-15-amino-5,7,9,11-tetrahydroxy-3,13-bis(4-methoxyb enzoyloxy)pentadec-1-yl) pivalate were prepared as well as (3R,5R,7R,9R,11S,13S)-1,15-d ...

2002

$ l _{ p } $ -Multiresolution Analysis: How to Reduce Ringing and Sparsify the Error

Michaël Unser, Thierry Blu

We propose to design the reduction operator of an image pyramid so as to minimize the approximation error in the

l _{ p }

-sense (not restricted to the usual p=2), where p can take non-integer values. The underlying image model is specified using shift- ...

IEEE2002

Derivatives of (2R,3R,4S)-2-Aminomethylpyrrolidine-3,4-diol are Selective alpha-Mannosidase Inhibitors

Pierre Vogel, Sandrine Gerber, Inmaculada Robina, Eliazar Rodriguez Garcia, Raynald Demange

A collection of (2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl derivatives have been tested for their inhibitory activities toward 25 glycosidases. Competitive (K-i=7.4 VM) and selective inhibition of alpha -mannosidase from jack bean has been found for (2R,3R,4S ...

2001

5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Pascal Uehlinger

Protoporphyrin IX (PpIX) is used as a fluorescence marker and photosensitizing agent in photodynamic therapy (PDT). A temporary increase of PpIX in tissues can be obtained by administration of 5-aminolevulinic acid (ALA). Lipophilicity is one of the key pa ...

2000

MAXENT priors for stochastic filtering problems

Giancarlo Ferrari Trecate

In the present paper, the problem of selecting priors for continuous-time processes is approached using the MaxEnt paradigm. First, assuming stationarity and Gaussianity, a suitable definition of differential entropy rate is introduced. Second, it is obser ...

1998

Synthesis of 4-hydroxy-2,6-bis(hydroxymethyl)tetrahydropyran-2-carbaldehyde derivatives

Pierre Vogel

Cycloaddition of 1,3-dibromo-2-oxyallyl cation to 2-(benzyloxymethyl)furan provided a 8-oxabicyclo[3.2.1]hept-6-en-3-one derivative that was transformed into (2RS,3SR,4SR,5SR,6SR)-3,4-dibromo-2-benzyloxymethyl-2,6-bis(hydroxymethy l)-4- (methoxymethyloxy)t ...

1998

Design, Synthesis and in vitro Controlled Release of New Adamantanodiarylketone Antimycobacterials

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Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles

Heterosubstituted or functionalized derivatives of 1- and 2-(trifluoromethyl)naphthalenes emanating from aryne adducts

Scope and limitations of the double [4+3]-cycloadditions of 2-oxyallyl cations to 2,2 '-methylenedifuran and derivatives

Metabolism of atrazine and derivatives in vetiver plants

Asymmetric synthesis of 1-aminopentadecane-3,5,7,9,11,13,15-heptols and of 1,15-diaminopentadecane-3,5,7,9,11,13-hexols and derivatives

$ l _{ p } $ -Multiresolution Analysis: How to Reduce Ringing and Sparsify the Error

Derivatives of (2R,3R,4S)-2-Aminomethylpyrrolidine-3,4-diol are Selective alpha-Mannosidase Inhibitors

5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells

MAXENT priors for stochastic filtering problems

Synthesis of 4-hydroxy-2,6-bis(hydroxymethyl)tetrahydropyran-2-carbaldehyde derivatives

Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles

Asymmetric synthesis of 1-aminopentadecane-3,5,7,9,11,13,15-heptols and of 1,15-diaminopentadecane-3,5,7,9,11,13-hexols and derivatives

$ l _{ p } $ -Multiresolution Analysis: How to Reduce Ringing and Sparsify the Error

Derivatives of (2R,3R,4S)-2-Aminomethylpyrrolidine-3,4-diol are Selective alpha-Mannosidase Inhibitors

Synthesis of 4-hydroxy-2,6-bis(hydroxymethyl)tetrahydropyran-2-carbaldehyde derivatives

Heterosubstituted or functionalized derivatives of 1- and 2-(trifluoromethyl)naphthalenes emanating from aryne adducts

Scope and limitations of the double [4+3]-cycloadditions of 2-oxyallyl cations to 2,2 '-methylenedifuran and derivatives

Metabolism of atrazine and derivatives in vetiver plants

MAXENT priors for stochastic filtering problems

5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells