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SPar-K: a method to partition NGS signal data

Philipp Bucher, Romain Fernand Pietro Groux
2019
Journal paper
Abstract

We present SPar-K (Signal Partitioning with K-means), a method to search for archetypical chromatin architectures by partitioning a set of genomic regions characterized by chromatin signal profiles around ChIP-seq peaks and other kinds of functional sites. This method efficiently deals with problems of data heterogeneity, limited misalignment of anchor points and unknown orientation of asymmetric patterns.

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