Publication
Efficient conversion of chemical energy into mechanical work by Hsp70 chaperones
Related publications (34)
Repair or Degrade: the Thermodynamic Dilemma of Cellular Protein Quality-Control
Paolo De Los Rios, Pierre Goloubinoff, Satyam Tiwari, Mathieu Rebeaud, Bruno Claude Daniel Fauvet
Life is a non-equilibrium phenomenon. Owing to their high free energy content, the macromolecules of life tend to spontaneously react with ambient oxygen and water and turn into more stable inorganic molecules. A similar thermodynamic picture applies to th ...
FRONTIERS MEDIA SA2021Uncertainty estimation for molecular dynamics and sampling
Michele Ceriotti, Federico Grasselli, Yongbin Zhuang, Venkat Kapil, Kevin Rossi, Edgar Albert Engel, Giulio Imbalzano
Machine-learning models have emerged as a very effective strategy to sidestep time-consuming electronic-structure calculations, enabling accurate simulations of greater size, time scale, and complexity. Given the interpolative nature of these models, the r ...
2021Characterising Structure and Stability of Materials using Machine Learning
The search of novel materials using in-silico high-throughput screening is emerging as a fundamental step in the pipeline of materials discovery, but its low yields in terms of synthesisable structures limit its effectiveness. In order to isolate configura ...
EPFL2020Membraneless organelles: phasing out of equilibrium
Over the past years, liquid-liquid phase separation (LLPS) has emerged as a ubiquitous principle of cellular organization implicated in many biological processes ranging from gene expression to cell division. The formation of biological condensates, like t ...
PORTLAND PRESS LTD2020Non-equilibrium kinetics and trajectory thermodynamics of synthetic molecular pumps
A major goal in the design of synthetic molecular machines is the creation of pumps that can use the input of energy to transport material from a reservoir at low chemical potential to a different reservoir at higher chemical potential, thereby forming and ...
ROYAL SOC CHEMISTRY2020Non equilibrium thermodynamics of protein organization
Three quarters of the thesis will be devoted to the discussion of non equilibrium systems.
We show how certain biological systems cannot be described by standard thermodynamics.
The reason is that the energy consumption due to the hydrolysis of ATP imposes ...
EPFL2018Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins
Paolo De Los Rios, Alessandro Barducci, Pierre Goloubinoff, Bruno Claude Daniel Fauvet, Alberto Stefano Sassi
During and after protein translation, molecular chaperones require ATP hydrolysis to favor the native folding of their substrates and, under stress, to avoid aggregation and revert misfolding. Why do some chaperones need ATP, and what are the consequences ...
2018The underappreciated role of nonvolatile cations in aerosol ammonium-sulfate molar ratios
Overprediction of fine-particle ammonium-sulfate molar ratios (R) by thermodynamic models is suggested as evidence for interactions with organic constituents that inhibit the equilibration of gas-phase ammonia with aerosol sulfate and questions the equilib ...
2018A comparison of Redlich-Kister polynomial and cubic spline representations of the chemical potential in phase field computations
Free energies play a central role in many descriptions of equilibrium and non-equilibrium properties of solids. Continuum partial differential equations (PDEs) of atomic transport, phase transformations and mechanics often rely on first and second derivati ...
Elsevier2017A universal chemical potential for sulfur vapours
The unusual chemistry of sulfur is illustrated by the tendency for catenation. Sulfur forms a range of open and closed S-n species in the gas phase, which has led to speculation on the composition of sulfur vapours as a function of temperature and pressure ...
Royal Soc Chemistry2016