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Adaptation of Pseudomonas aeruginosa to constant sub-inhibitory concentrations of quaternary ammonium compounds

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Recent advances in therapeutic targets identification and development of treatment strategies towards Pseudomonas aeruginosa infections

Grazia Vizzarro

The opportunistic human pathogen Pseudomonas aeruginosa is the causal agent of a wide variety of infections. This non-fermentative Gram-negative bacillus can colonize zones where the skin barrier is weakened, such as wounds or burns. It also causes infecti ...

BMC2023

In vitro synergistic action of TAT-RasGAP 317-326 peptide with antibiotics against Gram-negative pathogens

Grazia Vizzarro

Objectives: Multidrug-resistant (MDR) bacteria are a continuously increasing threat for medicine, caus-ing infections recalcitrant to antibiotics. Antimicrobial peptides (AMPs) were identified as alternatives to antibiotics, being naturally occurring short ...

ELSEVIER SCI LTD2022

Disinfection agents have been present in our daily lives for several decades in detergents or in personal care products, where their role is to prevent the spread of pathogenic microor-ganisms. One of the largest class of disinfection agents is quaternary ...

EPFL2021

P. aeruginosa (PA) continues to pose a threat to global public health due to its high levels of antimicrobial resistance (AMR). The ongoing AMR crisis has led to an alarming shortage of effective treatments for resistant microbes, and hence there is a pres ...

AMER CHEMICAL SOC2021

Pilus production in Acinetobacter baumannii is growth phase dependent and essential for natural transformation

Melanie Blokesch, Nina Vesel

Acinetobacter baumannii is a severe threat to human health as a frequently multidrug-resistant hospital-acquired pathogen. Part of the danger from this bacterium comes from its genome plasticity and ability to evolve quickly by taking up and recombining ex ...

2021

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Quaternary ammonium compounds (QACs) are among the most used disinfection agents in consumer products and in industrial applications. Because of their poor biodegradabil ity, after use, they will persist in technical and natural aquatic systems at sub - in ...

2019

The design, synthesis, fundamentals and evaluation of 2D/3D antimicrobial surfaces are addressed in detail in the current review. Recent advances in the antimicrobial mechanism, kinetics and properties of Ag, Cu and Ag-Cu surfaces in the dark and under lig ...

ELSEVIER SCIENCE BV2019

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Because of their high mutation rate, enteric virus populations excreted from a host are not clonal, but rather consist of a mutant cloud with many different genetic variants. Among these variants, the susceptibility to environmental stressors (e.g., temper ...

2019

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On-site generation of sodium hypochlorite (NaClO) holds the potential to bring an efficient and cost-effective water disinfection method to isolated and remote locations. Solar-driven, stand-alone reactors could provide those communities full independence ...

ELECTROCHEMICAL SOC INC2019

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The emergence of antibiotic resistance represents a major threat to human health. In this work we investigated the elimination of antibiotic resistant bacteria (ARB) by solar light and solar photo-Fenton processes. As such, we have designed an experimental ...

PERGAMON-ELSEVIER SCIENCE LTD2018