Non-invasive glucose sensor

An optical device for the in noninvasive determination of the concentration of glucose or another analyte in blood using a combination of Raman spectrometry and PPG. The device includes an optical detector, preferably a CMOS imager including pinned photodiodes (PPD) to collect a time-variable signal and a logic circuit arranged to determine a glucose concentration based on variations in the optical signal happening in a frequency range compatible with the cardiac rhythm.