Publications related to Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

COUP-TFII Controls Mouse Pancreatic beta-Cell Mass through GLP-1-beta-Catenin Signaling Pathways

Background: The control of the functional pancreatic beta-cell mass serves the key homeostatic function of releasing the right amount of insulin to keep blood sugar in the normal range. It is not fully understood though how beta-cell mass is determined. ...

2012

GLUT2-/- mice are resistant to age-induced accumulation of fat in the liver – an in vivo MRS study

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Introduction: Whole-body energy balance is strongly dependent on the hepatic handling of metabolic fuels, which is affected by the hepatic lipid content (HLC). With in vivo nuclear magnetic resonance spectroscopy (MRS) HLC can be measured non-invasively an ...

Wiley-Blackwell2012

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Chiara Greggio

The pancreas plays a central role in metabolism. The exocrine pancreas, composed of ductal and acinar cells, secretes and delivers digestive enzymes into the duodenum where they contribute to food digestion. The endocrine pancreas, constituted by the islet ...

EPFL2011

A Minimal Exercise Extension for Models of the Glucoregulatory System

Denis Gillet, Grégory François, Alain Bock, Thierry Prud'Homme

For patients with type 1 diabetes mellitus, appropriate control of blood glucose concentrations is vital. Exercise is one of the disturbances that can affect these concentrations. Therefore, predictions in the presence of exercise are useful among others f ...

Elsevier2011

Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

Kristina Schoonjans, Andreas Wiederkehr, Chikage Mataki

Mitochondrial Ca2+ signals have been proposed to accelerate oxidative metabolism and ATP production to match Ca2+-activated energy-consuming processes. Efforts to understand the signaling role of mitochondrial Ca2+ have been hampered by the inability to ma ...

Elsevier2011

The electro-deoxidation of dense titanium dioxide precursors in molten calcium chloride giving a new reaction pathway

Duncan Thomas Lindsay Alexander

A new study is presented on the electro-deoxidation of porous TiO2 precursors in molten calcium chlo- ride electrolytes. It is shown that by reducing precursor open porosity from standard values of ≥25% to ∼11–12%, such that there is insufficient free volu ...

Elsevier2011

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

Kristina Schoonjans, Andreas Wiederkehr, Chikage Mataki

Glucose-evoked mitochondrial signals augment ATP synthesis in the pancreatic β cell. This activation of energy metabolism increases the cytosolic ATP/ADP ratio, which stimulates plasma membrane electrical activity and insulin granule exocytosis. We have re ...

2010

Towards high resolution optical imaging of beta cells in vivo

Theo Lasser, Anne Grapin-Botton, Martin Villiger, Joan Goulley, Erica Martin-Williams

Endocrine beta cells produce and release insulin in order to tightly regulate glucose homeostasis and prevent metabolic pathologies such as Diabetes Mellitus. Optical imaging has contributed greatly to our current understanding of beta cell structure and f ...

Bentham Science Publishers2010

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Philipp Bucher

OBJECTIVE: Pancreatic islets of perinatal mice lacking the transcription factor Rfx3 exhibit a marked reduction in insulin-producing beta-cells. The objective of this work was to unravel the cellular and molecular mechanisms underlying this deficiency. RES ...

American Diabetes Association2010

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

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COUP-TFII Controls Mouse Pancreatic beta-Cell Mass through GLP-1-beta-Catenin Signaling Pathways

GLUT2-/- mice are resistant to age-induced accumulation of fat in the liver – an in vivo MRS study

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

A Minimal Exercise Extension for Models of the Glucoregulatory System

Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

The electro-deoxidation of dense titanium dioxide precursors in molten calcium chloride giving a new reaction pathway

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

Towards high resolution optical imaging of beta cells in vivo

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

GLUT2-/- mice are resistant to age-induced accumulation of fat in the liver – an in vivo MRS study

Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

The electro-deoxidation of dense titanium dioxide precursors in molten calcium chloride giving a new reaction pathway

COUP-TFII Controls Mouse Pancreatic beta-Cell Mass through GLP-1-beta-Catenin Signaling Pathways

Towards high resolution optical imaging of beta cells in vivo

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

A Minimal Exercise Extension for Models of the Glucoregulatory System