SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation
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Chromatin remodeling through histone posttranslational modifications (PTMs) and DNA methylation has recently been implicated in cognitive functions, but the mechanisms involved in such epigenetic regulation remain poorly understood. Here, we show that prot ...
A review. Histone deacetylase inhibitors are an emerging class of antiproliferative agents that have the potential to combat cancer on an epigenetic level. The recently reported marine natural product largazole was recently isolated in trace amts. from cya ...
An investigation on nano-structured electrodes to detect different metabolites is proposed in this paper. Three different metabolites are considered: glucose, lactate, and cholesterol. The direct detection of hydrogen peroxide is also considered since it d ...
Transcriptional control of metabolic circuits requires coordination between specific transcription factors and coregulators and is often deregulated in metabolic diseases. We characterized here the mechanisms through which the coactivator SRC-3 controls en ...
Following the seminal work of Von Dreele, high quality powder X-ray diffraction studies on proteins are being established as a valuable complementary technique to single-crystal measurements. Several studies using a variety of experiments approaches have b ...
Due to daylight variability, a design cannot be thoroughly assessed using single-moment simulations, which is why we need dynamic performance metrics like Daylight Autonomy and Useful Daylight Illuminance. Going one step further, the annual variation in pe ...
Homologues of Gpi8p, Gaa1p, Gpi16p, Gpi17p, and Cdc91p are essential components of the GPI transamidase complex that adds glycosylphosphatidylinositols (GPIs 1) to newly synthesized proteins in the ER. In mammalian cells, these five subunits remain stably ...
Particle filters are now established as the most popular method for visual tracking. Within this framework, it is generally assumed that the data are temporally independent given the sequence of object states. In this paper, we argue that in general the da ...
A heterodimer of importin alpha and importin beta accomplishes the nuclear import of proteins carrying classical nuclear localization signals (NLS). The interaction between the two import factors is mediated by the IBB domain of importin alpha and involves ...
Particle filters are now established as the most popular method for visual tracking. Within this framework, it is generally assumed that the data are temporally independent given the sequence of object states. In this paper, we argue that in general the da ...
