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Organohalide respiration in Firmicutes: energy metabolism and transcription regulation

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The present invention concerns a geosynthetic element (1) for a geotechnical engineering application. The geosynthetic element (1) comprises: bacteria carriers (3) for carrying bacteria arranged to be propagated from the geosynthetic element (1) to a surro ...

2018

Properties of Enzymes Involved in Tetrachloroethene Respiration

Géraldine Florence Buttet

Tetrachloroethene (PCE) pollution threatens nature and human health due to its toxic and carcinogenic potential. Due to industrial activities, large amounts of PCE were discharged into the environment over the last decades and represent one of major ground ...

EPFL2017

Functional Characterization of Nucleoid Associated Proteins Acting as Global Transcription Factors in Mycobacterium tuberculosis

Nina Theres Odermatt

The fatal lung disease tuberculosis is caused by the airborne Mycobacterium tuberculosis, a versatile pathogen adapted to rapidly changing environments. Instead of being eradicated by phagocytic cells of its human host, bacilli tune macrophages to support ...

EPFL2017

Dehalobacter – a genus of anaerobic bacteria dedicated to organohalide degradation

Christof Holliger, Julien Maillard

Abstract The genus Dehalobacter embraces bacterial populations that seem to exclusively degrade organohalides. All isolates in pure culture and highly enriched strains are obligate organohalide-respiring bacteria that use hydrogen as energy and electron so ...

Springer-Verlag2016

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We present a model-based method, designated Inverse Metabolic Control Analysis (IMCA), which can be used in conjunction with classical Metabolic Control Analysis for the analysis and design of cellular metabolism. We demonstrate the capabilities of the met ...

Academic Press Inc Elsevier Science2016

Reductive dehalogenases (rdhA, RDases) are key enzymes involved in anaerobic organohalide respiration (OHR), during which bacteria are able to use chlorinated compounds as terminal electron acceptors. RDases are redox enzymes containing FeS clusters and a ...

2016

Do crosstalks with primary and secondary metabolism limit or stimulate the detoxification of xenobiotics?

Jean-Paul Schwitzguebel

Because plants are static and live in a competitive and sometimes hostile environment, they have evolved efficient mechanisms that protect them from abiotic and biotic stresses. These mechanisms include detoxification and sequestration of xenobiotic compou ...

2014

The Crystal Structures of Apo and cAMP-Bound GlxR from Corynebacterium glutamicum Reveal Structural and Dynamic Changes upon cAMP Binding in CRP/FNR Family Transcription Factors

Stewart Cole, Florence Pojer

The cyclic AMP-dependent transcriptional regulator GlxR from Corynebacterium glutamicum is a member of the super-family of CRP/FNR (cyclic AMP receptor protein/fumarate and nitrate reduction regulator) transcriptional regulators that play central roles in ...

Public Library of Science2014

Transcriptional Coregulators: Fine-Tuning Metabolism

Johan Auwerx, Laurent Mouchiroud

Metabolic homeostasis requires that cellular energy levels are adapted to environmental cues. This adaptation is largely regulated at the transcriptional level, through the interaction between transcription factors, coregulators, and the basal transcriptio ...

Elsevier2014

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Dehalobacter restrictus strain PER-K23 is an obligate organohalide respiring microorganism known to solely use tetra- or trichloroethene as electron acceptors with H2 as electron donor. The catalytic enzyme, PceA, contains a corrinoid as cofactor, a trait ...

2014