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The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation
Related publications (78)
Relation of effective arterial elastance to arterial system properties
Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof
Effective arterial elastance (E(a)), defined as the ratio of left ventricular (LV) end-systolic pressure and stroke volume, lumps the steady and pulsatile components of the arterial load in a concise way. Combined with E(max), the slope of the LV end-systo ...
2002Dilated cardiomyopathy and impaired cardiac hypertrophic response to angiotensin II in mice lacking FGF-2
FGF-2 has been implicated in the cardiac response to hypertrophic stimuli. Angiotensin II (Ang II) contributes to maintain elevated blood pressure in hypertensive individuals and exerts direct trophic effects on cardiac cells. However, the role of FGF-2 in ...
American Society for Clinical Investigation2001Quantification of the contribution of cardiac and arterial remodeling to hypertension
Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof
The study aim was to quantify the individual and combined contributions of both the arterial system and the heart to systolic blood pressure in hypertension. We assessed the parameters of a heart-arterial model for normotensive control subjects and hyperte ...
2000Left ventricular wall stress normalization in chronic pressure-overloaded heart: a mathematical model study
Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof
It is generally accepted that the left ventricle (LV) hypertrophies (LVH) to normalize systolic wall stress (sigma(s)) in chronic pressure overload. However, LV filling pressure (P(v)) may be elevated as well, supporting the alternative hypothesis of end-d ...
2000