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Modeling synchronization in globally coupled oscillatory systems using model order reduction
Related publications (32)
Statistical physics of periodic biological processes
Earth rotation around its axis imposes a 24-hour rhythmicity to all life on the planet.Rather than passively responding to these periodic changes, nature has given us an internal timekeeper, the circadian clock, to anticipate to our advantage the fluctuati ...
EPFL2023Comment on "Circadian rhythms in the absence of the clock gene Bmal1"
Ray et al. (Reports, 14 February 2020, p. 800) recently claimed temperature-compensated, free-running mRNA oscillations in Bmal1(-/-) liver slices and skin fibroblasts. We reanalyzed these data and found far fewer reproducible mRNA oscillations in this gen ...
2021Low-dimensional dynamics of two coupled biological oscillators
Felix Naef, Eric Paquet, Colas Noé Droin
The circadian clock and the cell cycle are two biological oscillatory processes that coexist within individual cells. These two oscillators were found to interact, which can lead to their synchronization. Here, we develop a method to identify a low-dimensi ...
NATURE PUBLISHING GROUP2019Tissue-specific circadian transcriptional regulation
Circadian rhythms in physiology and behavior evolved to resonate with daily cycles in the external environment. In mammals, organs orchestrate temporal physiology over the 24-hour day, which requires extensive gene expression rhythms targeted to the right ...
EPFL2019Circadian rhythms and proteomics: It's all about posttranslational modifications!
Daniel Alain Dominique Marie Mauvoisin
The circadian clock is a molecular endogenous timekeeping system and allows organisms to adjust their physiology and behavior to the geophysical time. Organized hierarchically, the master clock in the suprachiasmatic nuclei, coordinates peripheral clocks, ...
WILEY2019Circadian Rhythms and Mitochondria: Connecting the Dots
Carlos Canto Alvarez, Miriam Valera Alberni
Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment of circadian rhythms is associated with increased risk of type 2 diabetes and emerging evi ...
FRONTIERS MEDIA SA2018Rhythms of the Genome: Circadian Dynamics from Chromatin Topology, Tissue-Specific Gene Expression, to Behavior
Circadian rhythms in physiology and behavior evolved to resonate with daily cycles in the external environment. In mammals, organs orchestrate temporal physiology over the 24-h day, which requires extensive gene expression rhythms targeted to the right tis ...
ELSEVIER SCIENCE LONDON2018Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World
Felix Naef, Jake Yeung, Jérôme Mermet
Mammals have evolved an internal timing system, the circadian clock, which synchronizes physiology and behavior to the daily light and dark cycles of the Earth. The master clock, located in the suprachiasmatic nucleus (SCN) of the brain, takes fluctuating ...
Cold Spring Harbor Lab Press, Publications Dept2017Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World
Felix Naef, Jake Yeung, Jérôme Mermet
Mammals have evolved an internal timing system, the circadian clock, which synchronizes physiology and behavior to the daily light and dark cycles of the Earth. The master clock, located in the suprachiasmatic nucleus (SCN) of the brain, takes fluctuating ...
Cold Spring Harbor Lab Press, Publications Dept2017Stem cells and the circadian clock
Benjamin Dieter Weger, Meltem Weger
The circadian timing system is a complex biological network of interacting circadian clocks that regulates 24 h rhythms of behavioral and physiological processes. One intriguing observation is that stem cell homeostasis is subject to circadian clock regula ...
Academic Press Inc Elsevier Science2017