Structural basis of drug recognition by the multidrug transporter ABCG2
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Examining the performance of an existing bridge requires information on several aspects, such as design choices, material properties, and ongoing degradation processes. It often happens that some critical information is not available. The traditional appro ...
2024
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ABCG2 is a multidrug transporter that affects drug pharmacokinetics and contributes to multidrug resistance of cancer cells. In previously reported structures, the reaction cycle was halted by the absence of substrates or ATP, mutation of catalytic residue ...
NATURE RESEARCH2021
Over the past decades, timber has gained popularity as a sustainable building material because of the rising environmental awareness. Furthermore, the resurgence of timber has also been encouraged by the advent of the digital age during the 21st century. T ...
EPFL2020
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Current load-bearing systems for buildings rarely have a beneficial end of life. Modular design is a proven solution for revalorizing obsolete structures, but it hardly competes with conventional solutions: the range of future spatial configurations that t ...
World Sustainable Built Environment2020
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With recent advances in digital fabrication, innovative wood-wood connections inspired by ancient timber joining techniques have recently been applied to various free-form timber plate structures [1]. This paper focuses on the recently developed double-lay ...
2019
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With recent advances in digital fabrication, innovative wood-wood connections inspired by ancient timber joining techniques have recently been applied to various free-form timber plate structures. This paper focuses on the recently developed double-layered ...
International Centre for Numerical Methods in Engineering (CIMNE)2019
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Sensor-based occupant tracking has the potential to enhance knowledge of the utilization of buildings. Occupancy-tracking strategies using footstep-induced floor vibrations may be beneficial for thermal-load prediction, security enhancement, and care-givin ...
2019
This thesis applies structural optimization techniques to develop a general methodology for design from reuse. A thorough case study serves as proof-of-concept. Reusing elements from dismantled structures appears as a promising, yet little explored approac ...
ABCG2 is an ATP-binding cassette transporter that exports a wide range of xenobiotic compounds and has been recognized as a contributing factor for multidrug resistance in cancer cells. Substrate and inhibitor interactions with ABCG2 have been extensively ...
The management of existing civil infrastructure is becoming more crucial as a large share of bridges is approaching their theoretical end of service duration. Structural performance monitoring aims to verify bridge safety at a given time, and it should be ...
