Publication
Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions
Related publications (57)
Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae
Alexandre Louis André Persat, Sofya Mikhaleva
Biofilm formation is generally recognized as a bacterial defense mechanism against environmental threats, including antibiotics, bacteriophages, and leukocytes of the human immune system. Here, we show that for the human pathogen Vibrio cholerae, biofilm f ...
CELL PRESS2023Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy
Chimeric antigen receptors (CARs) are synthetic, transmembrane proteins that trigger immune cell signaling following their engagement. They have been first utilized in T cells and later in natural killer (NK) cells to redirect their cytotoxicity toward a s ...
EPFL2023Observed Kinetics of Enterovirus Inactivation by Free Chlorine Are Host Cell-Dependent
Tamar Kohn, Shannon Christa David, Shotaro Torii, Federica Cariti
Virucidal efficacies of disinfectants are typically assessed by infectivity assay utilizing a single type of host cell. Enteroviruses infect multiple host cells via various entry routes, and each entry route may be impaired differently by a given disinfect ...
2023Engineering Agrobacterium tumefaciens Adhesion to Target Cells
Alexandre Louis André Persat, Xavier Jean-Yves Pierrat, Jeremy Pak Hei Wong, Alix Kim Lan Pham
Agrobacterium tumefaciens is a plant pathogen commonly repurposed for genetic modification of crops. Despite its versatility, it remains inefficient at transferring DNA to many hosts, including to animal cells. Like many pathogens, physical contact between ...
AMER CHEMICAL SOC2022