Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI)
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The auditory brainstem implant (ABI) restores hearing in patients with damaged auditory nerves. One of the main ideas to improve the efficacy of ABIs is to increase spatial specificity of stimulation, in order to minimize extra-auditory side-effects and to ...
Optogenetics has become an important research tool and is being considered as the basis for several neural prostheses. However, few studies have applied optogenetics to the auditory brainstem. This study explored whether optical activation of the cochlear ...
This thesis focuses on the study of H6 homeobox 1 (HMX1) gene, a homeobox-containing transcription factor involved in sensory organ and eye development and responsible for the oculo-auricular syndrome of Schorderet-Munier-Franceschetti. The purpose of my s ...
Visual deficits in schizophrenic patients are of particular interest because they reflect the deficient circuits of information processing in the brain. In our previous work, we showed that schizophrenic patients have decreased peak amplitudes and reduced ...
The aim of this project is to study the use of pulsed infrared laser light to stimulate the central auditory system. This novel approach may be a means to improve the efficacy of the current generation of electrically based Auditory Brainstem Implants (ABI ...
Researchers have succeeded in partly restoring damaged vestibular functionality in several animal models. Recently, acute interventions have also been demonstrated in human patients. Our previous work on a vestibular implant for humans used predefined stim ...
Introduction: Flankers can strongly deteriorate performance on a visual target (crowding). For example, vernier offset discrimination is strongly affected by neighboring flankers. Interestingly, performance for longer and shorter flankers is better than pe ...
Organic bioelectronics aims at the intimate integration between organic materials and biological tissues in order to obtain a targeted functional outcome. In the last decades, conductive polymers have been successfully employed to interface excitable cells ...
2015
In an effort to improve the auditory brainstem implant, a prosthesis in which user outcomes are modest, we applied electric and infrared neural stimulation (INS) to the cochlear nucleus in a rat animal model. Electric stimulation evoked regions of neural a ...
Background: Earlier contributions have documented significant changes in sensory, attention-related endogenous event-related potential (ERP) components and theta band oscillatory responses during working memory activation in patients with schizophrenia. In ...