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Gene expression patterns associated with multidrug therapy in multibacillary leprosy

Related publications (88)

Neurobehavioural activation during peripheral immunosuppression

Like other physiological responses, immune functions are the subject of behavioural conditioning. Conditioned immunosuppression can be induced by contingently pairing a novel taste with an injection of the immunosuppressant cyclosporine A (CsA) in an assoc ...

2013

Image thresholding techniques for localization of sub-resolution fluorescent biomarkers

Giovanni De Micheli, Sandro Carrara, Paolo Silacci, Julien Michel Ghaye, Madhura Avinash Kamat, Guy Vergères

In this article, we explore adaptive global and local segmentation techniques for a lab-on-chip nutrition monitoring system (NutriChip). The experimental setup consists of Caco-2 intestinal cells that can be artificially stimulated to trigger an immune res ...

Wiley-Blackwell2013

Brillouin distributed fibre sensing using phase modulated probe

Luc Thévenaz, Marcelo Alfonso Soto Hernandez, Xin Lu

A novel configuration for a Brillouin distributed sensor using a phase modulated probe is presented. It offers the combined advantages of a direct implementation using simple devices and a large immunity to noise, shifting the information from the baseband ...

Spie-Int Soc Optical Engineering2013

Gene Expression Profile of Peripheral Blood Lymphocytes from Renal Cell Carcinoma Patients Treated with IL-2, Interferon-α and Dendritic Cell Vaccine

Benita Wolf

Lymphocytes are a key component of the immune system and their differentiation and function are directly influenced by cancer. We examined peripheral blood lymphocyte (PBL) gene expression as a biomarker of illness and treatment effect using the Affymetrix ...

Public Library of Science2012

A Generalized Mathematical Model To Estimate T- and B-Cell Receptor Diversities Using AmpliCot

Jean-Yves Le Boudec, Irina Baltcheva

The efficiency of the adaptive immune system is dependent on the diversity of T- and B-cell receptors, which is created by random rearrangement of receptor gene segments. AmpliCot is an experimental technique that allows the measurement of the diversity of ...

Elsevier2012

Improving Immunogenicity of Subunit Vaccines Using Nanocarrier Systems

Armando Stano

New generation vaccines, which are subunit vaccines, have considerably improved safety profiles, but are often poorly immunogenic, especially when administered through mucosal routes. Also, the diversity of the mechanisms of action of infectious pathogens ...

EPFL2012

Gene expression analysis of metastases and IL-1R1 characterization in a NALP3 mouse model

Heidi Fournier

Tumor microenvironment contributes strongly to tumor evolution toward metastasis, a final stage in cancer progression. It provides essential clues to promote migration of cancer cells in metastatic sites. Moreover, inflammatory cells and immunomodulatory m ...

2011

Elucidating the mechanisms of paclitaxel-loaded-nanoparticle-induced immune response

Efthymia Vokali

Dentritic cells (DC) are the most potent antigen-presenting cells and play a key role in the induction of effective immune responses, suggesting a novel target for anti-tumor immunotherapy. Paclitaxel (PXL) is a widely used chemotherapeutic, initially char ...

2011

Local glucocorticoid production in the mouse lung is induced by immune cell stimulation

Kristina Schoonjans

Background: Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive steroid hormones, mainly produced by the adrenal glands. However, increasing evidence supports the idea of additional extra-adrenal sources of bioactive GC. The lung epithe ...

Wiley-Blackwell2011

The Role of c-di-AMP in Listeria monocytogenes

Matthieu Jean-Hubert Delincé

L. monocytogenes is a Gram-positive intracellular pathogen that can cause serious disease, like septicemia and meningitis. It is detected in the cytosol by the innate immune system by sensing pathogen ligands. c-di-AMP has recently been shown to be one of ...

2011

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