Biological targetA biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function. Examples of common classes of biological targets are proteins and nucleic acids. The definition is contcan refer to the biological target of a pharmacologically active drug compound, the receptor target of a hormone (like insulin), or some other target of an external stimulus.
Carboxylic acidIn organic chemistry, a carboxylic acid is an organic acid that contains a carboxyl group () attached to an R-group. The general formula of a carboxylic acid is or , with R referring to the alkyl, alkenyl, aryl, or other group. Carboxylic acids occur widely. Important examples include the amino acids and fatty acids. Deprotonation of a carboxylic acid gives a carboxylate anion. Carboxylic acids are commonly identified by their trivial names. They often have the suffix -ic acid.
Law libraryA law library is a special library used by law students, lawyers, judges and their law clerks, historians and other scholars of legal history in order to research the law. Law libraries are also used by people who draft or advocate for new laws, e.g. legislators and others who work in state government, local government, and legislative counsel offices or the U.S. Office of Law Revision Counsel and lobbying professionals. Self-represented, or pro se, litigants (parties to a civil lawsuit or criminal defendants who do not have a licensed attorney representing them) also use law libraries.
Cyclic guanosine monophosphateCyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP. Its most likely mechanism of action is activation of intracellular protein kinases in response to the binding of membrane-impermeable peptide hormones to the external cell surface. Through protein kinases activation, cGMP can relax smooth muscle. cGMP concentration in urine can be measured for kidney function and diabetes detection.
Thin-film drug deliveryThin-film drug delivery uses a dissolving film or oral drug strip to administer drugs via absorption in the mouth (buccally or sublingually) and/or via the small intestines (enterically). A film is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity, delivering the drug to the systemic circulation via dissolution when contact with liquid is made. Thin-film drug delivery has emerged as an advanced alternative to the traditional tablets, capsules and liquids often associated with prescription and OTC medications.
Oral poetryOral poetry is a form of poetry that is composed and transmitted without the aid of writing. The complex relationships between written and spoken literature in some societies can make this definition hard to maintain. Oral poetry is sometimes considered to include any poetry which is performed live. In many cultures, oral poetry overlaps with, or is identical with, song. Meanwhile, although the term oral etymologically means 'to do with the mouth', in some cultures oral poetry is also performed by other means, such as talking drums in some African cultures.
Oral traditionOral tradition, or oral lore, is a form of human communication wherein knowledge, art, ideas and cultural material is received, preserved, and transmitted orally from one generation to another. The transmission is through speech or song and may include folktales, ballads, chants, prose or poetry. In this way, it is possible for a society to transmit oral history, oral literature, oral law and other knowledge across generations without a writing system, or in parallel to a writing system.
Methyl celluloseMethyl cellulose (or methylcellulose) is a compound derived from cellulose. It is sold under a variety of trade names and is used as a thickener and emulsifier in various food and cosmetic products, and also as a bulk-forming laxative. Like cellulose, it is not digestible, non-toxic, and not an allergen. In 2020, it was the 422nd most commonly prescribed medication in the United States, with more than 100 thousand prescriptions. Methyl cellulose has a wide range of uses. Methyl cellulose is used to treat constipation.
Oral literatureOral literature, orature or folk literature is a genre of literature that is spoken or sung as opposed to that which is written, though much oral literature has been transcribed. There is no standard definition, as anthropologists have used varying descriptions for oral literature or folk literature. A broad conceptualization refers to it as literature characterized by oral transmission and the absence of any fixed form. It includes the stories, legends, and history passed through generations in a spoken form.
MyristoylationMyristoylation is a lipidation modification where a myristoyl group, derived from myristic acid, is covalently attached by an amide bond to the alpha-amino group of an N-terminal glycine residue. Myristic acid is a 14-carbon saturated fatty acid (14:0) with the systematic name of n-tetradecanoic acid. This modification can be added either co-translationally or post-translationally. N-myristoyltransferase (NMT) catalyzes the myristic acid addition reaction in the cytoplasm of cells.
