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Article Structure and functionality of a multimeric human COQ7:COQ9 complex

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Towards a kinetic model of the phospholipids biosynthesis of the yeast Saccharomyces cerevisiae

Vassily Hatzimanikatis, Meriç Ataman, Georgios Savoglidis, Iro Oikonomidi

Lipids, as vital eukaryotic cellular components, play a major role in cell, tissue and organ physiology. Alterations of lipid enzymes and metabolic pathways are related to many human diseases, such as cancer, diabetes and neurodegenerative diseases. In thi ...

2014

A comprehensive reconstruction of the fatty acid biosynthesis in Saccharomyces cerevisiae

Vassily Hatzimanikatis, Georgios Savoglidis, Iro Oikonomidi

The role of lipids in eukaryotic cells is of high importance. They are one of the main components of cell membranes, act as storage of high potential energy as well as being a scaffold of signaling proteins or participate in signaling themselves. Many dise ...

2013

Integrating omics data into metabolic models of lipids: a platform for the identification of gene mutations from lipidomics data

Vassily Hatzimanikatis, Paolo Angelino, Howard Riezman, Georgios Savoglidis

Kinetic models of metabolic networks are mapping the biochemical reactions taking part in a cell to a mathematical representation. They are the blueprints of the biochemical network, connecting enzymatic activities and metabolic compounds. Kinetic models h ...

2013

Over the past years, molecular modeling and simulation techniques have had a major impact on experimental life sciences. They are capable of providing accurate insight into microscopic mechanisms, which are usually difficult to investigate experimentally. ...

EPFL2013

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The serine hydrolase, fatty acid amide hydrolase (FAAH), is responsible for the intracellular degradation of anandamide and other bioactive fatty acid ethanolamides involved in the regulation of pain, inflammation, and other pathophysiological processes. T ...

Amer Chemical Soc2013

A Biochemical and Biophysical Investigation of 5-HT3 Receptor Stability

Menno Berend Tol

The 5-hydroxytryptamine 3 receptor (5-HT3R) is a member of the pentameric ligand-gated ion channel (pLGIC) family, that plays an important role in fast signal transduction and cell-cell communication in synapses: They convert a chemical signal from a neuro ...

EPFL2012

Connecting vesicular transport with lipid synthesis: FAPP2

Giovanni D'Angelo

Next to the protein-based machineries composed of small G-proteins, coat complexes, SNAREs and tethering factors, the lipid-based machineries are emerging as important players in membrane trafficking. As a component of these machineries, lipid transfer pro ...

2012

Membrane stress tensor in the presence of lipid density and composition inhomogeneities

Anne-Florence Raphaëlle Bitbol

We derive the expression of the stress tensor for one-and two-component lipid membranes with density and composition inhomogeneities. We first express the membrane stress tensor as a function of the free-energy density by means of the principle of virtual ...

Springer Nature2011

We present a molecular dynamics study on the interaction of styryl-type voltage-sensitive dyes with a lipid membrane. In this work, voltage-sensitive dyes are proposed as interesting model amphiphiles for biomolecular simulation, due to the wealth of bioph ...

2009

Lipid-transfer proteins in biosynthetic pathways

Compartmentalization is a defining feature of eukaryotic cells that allows the spatial segregation of different functions, such as protein and lipid synthesis, and ensures their fidelity and efficiency. This imposes the need for an intense flux of metaboli ...

2008