AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn(2B/-) spinal muscular atrophy mice
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Mathematical modelling of the human heart and its function can expand our understanding of various cardiac diseases, which remain the most common cause of death in the developed world. Like other physiological systems, the heart can be understood as a comp ...
The Duchenne and Becker muscular dystrophies are caused by mutation of dystrophin gene and primarily affect skeletal and cardiac muscles. Cardiac involvement in dystrophic GRMD dogs has been demonstrated by electrocardiographic studies with the onset of a ...
The cytoskeleton is a highly dynamical protein network that plays a central role in numerous cellular physiological processes, and is traditionally divided into three components according to its chemical composition, i.e. actin, tubulin and intermediate fi ...
In this project we numerically simulate electrophysiological models for cardiac applications by means of Isogeometric Analysis. Specifically, we aim at understanding the advantages of using high order continuous NURBS (Non-UniformRational B-Splines) basis ...
We have used the Wide Field Spectrograph on the 2.3 m telescope at Siding Spring Observatory to map the [O III] lambda 5007 dynamics of the young oxygen-rich supernova remnant 1E 0102.2-7219 in the Small Magellanic Cloud. From the resultant data cube, we h ...
Cardiovascular diseases, including myocardial infarction, are the leading cause of death worldwide for both men and women. Current therapies are limited by the restricted intrinsic regeneration capacity of the heart and by the lack of organs for transplant ...
Activation of endogenous cardiac stem/progenitor cells (eCSCs) can improve cardiac repair after acute myocardial infarction. We studied whether the in situ activation of eCSCs by insulin-like growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) could ...
Knowledge of frictional forces acting on the tips of minimally invasive medical devices is important in the design and simulation of such devices. Moreover, several studies have shown that uncontrolled frictional forces can induce damage to organs. The goa ...
Barth syndrome is an X-linked genetic disorder caused by mutations in the tafazzin (taz) gene and characterized by dilated cardiomyopathy, exercise intolerance, chronic fatigue, delayed growth, and neutropenia. Tafazzin is a mitochondrial transacylase requ ...
The mechanical interactions between heart contraction and perfusion of the heart are difficult to study in humans because of the restrictions in inducing changes in hemodynamic and cardiac mechanics parameters during catheterization. We hypothesize that th ...
