Publication
Exploring the interplay of molecular pattern and valency for selective interactions at the bio-interface
Related publications (121)
The Contorsbody, an antibody format for agonism: design, structure, and function
The careful design of the antibody architecture is becoming more and more important, especially when the purpose is agonism. We present the design of a novel antibody format that is able to promote receptor dimerization and induce signal transduction resul ...
2020Biotechnologies to tackle the challenge of neoantigen identification
Philippe Renaud, George Coukos, Margaux Catherine Marie Duchamp, Alexandre Harari, Marion Arnaud
Among immune correlates of clinical responses, tumor-specificneoantigens took the spotlight as relevant targets for cancerimmunotherapy. The implementation of pipelines forpersonalized cancer therapy remains challenging due to theprivacy, that is patient-s ...
2020The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions
LRH-1 (liver receptor homolog-1/NR5a2) is an orphan nuclear receptor, which regulates glucose and lipid metabolism, as well as intestinal inflammation via the transcriptional control of intestinal glucocorticoid synthesis. Predominantly expressed in epithe ...
American Association for the Advancement of Science (AAAS)2019Label-free plasmonic biosensors for real-time live cell analysis
For decades, the understanding of life has been focused on its most fundamental building blocks: molecules. Deciphering the dynamic activities of protein molecules in human cells is of vital significance for fundamental and clinical studies. The minuscule ...
EPFL2019Simultaneous dual-contrast three-dimensional imaging in live cells via optical diffraction tomography and fluorescence
Christian Depeursinge, Pierre Marquet, Chen Liu, Shanshan Kou
We report a dual-contrast method of simultaneously measuring and visualizing the volumetric structural information in live biological samples in three-dimensional (3D) space. By introducing a direct way of deriving the 3D scattering potential of the object ...
2019DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity
High specificity accompanied with the ability to recruit immune cells has made recombinant therapeutic antibodies an integral part of drug development. Here we present a generic approach to generate two novel IgG-derived antibody formats that are based on ...
Informa UK Limited2019Targeted protein degradation through cytosolic delivery of monobody binders using bacterial toxins
Oliver Hantschel, Nadine Eliane Schmit, Katyayanee Neopane
Monobodies are small engineered binding proteins that, upon expression in cells, can inhibit signaling of cytosolic oncoproteins with outstanding selectivity. Efficacy may be further increased by inducing degradation of monobody targets through fusion to t ...
2019Development of a nano-adjuvant cancer vaccine and its evaluation for melanoma in combination with radiotherapy
Cancer is the second leading cause of death in the world and melanoma is the deadliest type of skin cancer. Although surgery, radiotherapy and chemotherapy are still standard treatments, the discovery of the role played by the immune system in cancer has a ...
EPFL2018New roles of the lymphatic endothelium in modulating adaptive immunity: implications for immune tolerance and cancer immunotherapy
Lambert Charles François Potin
Lymphatic vessels have traditionally been considered as passive conduits for interstitial fluid drainage and for immune cell trafficking to lymph nodes. In the last two decades, many studies have challenged this classical dogma: lymphatic endothelial cells ...
EPFL2018