Mechanism of KRAS-driven T cell infiltration in colorectal cancer
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Dendritic cells (DCs) are specialized myeloid cells with the ability to uptake, process, andpresent antigens to T lymphocytes. They also generate cytokine and chemokine gradients thatregulate immune cell trafficking, activation, and function. Monocyte-deri ...
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Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal diversity, yet uncontrolled replicative stress leads to mitotic catastrophe and inflammatory responses that promote immune rejection. KRAB domain-containing zinc fin ...
The present invention relates to 6-diazo-5-oxo-L-norleucine prodrugs having reduced toxicity and increased tumor specificity and to their therapeutic use for treating cancer. ...
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