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Microsecond Time-Resolved Cryo-Electron Microscopy

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Ferroelectric perovskite oxides are widely used in sensors, actuators and optical modulators and, at the same time, they show promise for implementation in future applications such as energy storage, memory and cooling devices. At the infancy of the discov ...

EPFL2022

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Spatiotemporal electron-beam shaping is a bold frontier of electron microscopy. Over the past decade, shaping methods evolved from static phase plates to low-speed electrostatic and magnetostatic displays. Recently, a swift change of paradigm utilizing lig ...

AMER CHEMICAL SOC2022

In the present paper, calcium deficient hydroxyapatite (Ca-def OHAP) has been examined in a transmission electron microscope. During the observation, the initial Ca-def OHAP was seen to transform first into a transient intermediate phase, then to a final, ...

WALTER DE GRUYTER GMBH2022

The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of ...

2022

The true understanding of most cellular functions is only really achievable through the structural determination of their underlying macromolecular assemblies. However, their size, large number of individual components and metastable states make their eluc ...

EPFL2021

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Proteins typically undergo dynamics on the microsecond to millisecond timescale, which is much faster than the time resolution of cryo-electron microscopy. Here, we propose a novel approach for microsecond time-resolved cryo-electron microscopy that involv ...

2021

Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly

Georg Fantner, Georgios Hatzopoulos, Tatiana Favez, Oliver Hantschel, Virginie Hamel, Niccolo Banterle, Santiago Harald Andany

Centrioles are evolutionarily conserved multi-protein organelles essential for forming cilia and centrosomes. Centriole biogenesis begins with self-assembly of SAS-6 proteins into 9-fold symmetrical ring polymers, which then stack into a cartwheel that sca ...

NATURE RESEARCH2021

Identification of a Dps contamination in Mitomycin-C–induced expression of Colicin Ia

Henning Paul-Julius Stahlberg

Colicins are bacterial toxins targeting Gram-negative bacteria, including E. coli and related Enterobacteriaceae strains. Some colicins form ion-gated pores in the inner membrane of attacked bacteria that are lethal to their target. Colicin Ia was the firs ...

2021

In recent decades, in situ electron microscopy has attracted considerable attention. The method enables real time observations of the transformations of nanoparticles under various stimuli with atomic spatial resolution. Time-resolved electron microscopy ...

EPFL2021

Longitudinal and transverse modulation of electron wave function with light, and its application to electron microscopy

Fabrizio Carbone, Giovanni Maria Vanacore, Ivan Madan, Enrico Pomarico, Gabriele Berruto, Ido Kaminer

Conventional electron microscopy operates with flat electron wave fronts. Employing attenuative or electrostatic phase plates allows transversally modulating the wave front, enhancing cross-sections of particular scattering channels. Utilization of light f ...

IEEE2021