Publication
Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers
Related publications (42)
Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis
Nearly all the cells of an organism share the same DNA sequence or genome, and yet they show different phenotypes and carry out different functions. This diversity is made possible by a verity of molecular modifications acting on the DNA sequence that coll ...
EPFL2020Development of chemical biology tools to reveal the function and organization of the silenced chromatin state
Effector proteins are recruited to chromatin via transient interactions between their reader domains and histone post-translational modification (PTM) patterns. These interactions form signaling pathways that control gene expression or repression and which ...
EPFL2020Modeling metabolic and signaling pathways in cancer cells
Cancer is a leading cause of death in the world, and the mechanisms that underlie this disease are still not completely understood. As cancer develops and progresses, cells undergo a diversity of mutations that sustain their rapid proliferation and the eva ...
EPFL2020Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV+ Cancers
Douglas Hanahan, Nadine Fournier, Mélanie Louise Tichet, Melody Swartz, Stephan Wullschleger, Gabriele Galliverti
Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. However, advanced forms of cervical cancer, driven by HPV, are poorly responsive to immune response-enhancing ...
AMER ASSOC CANCER RESEARCH2020Home-based HPV self-sampling assisted by a cloud-based electronic data system: Lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia
Primary HPV testing and triage of HPV-positive women is an effective cervical cancer screening strategy. Such a multi-visit screening algorithm is also promising for community-based screening in resource-poor communities, provided a robust tracking system ...
2020A Tale of Two Tumors: Unraveling the Complexities of Epigenetic Dysregulation in Cancer
Epigenetics plays an important role in cancer development and progression. Cancer cells hijack the epigenome by modifying the histone protein units responsible for packaging DNA, or by modifying the DNA itself, resulting in changes to chromatin topology an ...
EPFL2019Chromatin three-dimensional interactions mediate genetic effects on gene expression
David Hacker, Giovanna Ambrosini, Philipp Bucher, Sanjeev Kumar
Studying the genetic basis of gene expression and chromatin organization is key to characterizing the effect of genetic variability on the function and structure of the human genome. Here we unravel how genetic variation perturbs gene regulation using a da ...
2019EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains
Suliana Manley, Elisa Oricchio, Kyle Michael Douglass, Daniele Tavernari, Natalya Katanayeva, Elena Battistello, Stephanie Jocelyne Sungalee, Maria Christine Donaldson, Timo Henry René Rey, Giovanni Ciriello, Marco Mina
Chromatin is organized into topologically associating domains (TADs) enriched in distinct histone marks. In cancer, gain-of-function mutations in the gene encoding the enhancer of zeste homolog 2 protein (EZH2) lead to a genome-wide increase in histone-3 L ...
2019Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes
Denis Duboule, Lucille Delisle, Edgardo Rodriguez Carballo, Nayuta Yakushiji
Background The spatial organization of the mammalian genome relies upon the formation of chromatin domains of various scales. At the level of gene regulation in cis, collections of enhancer sequences define large regulatory landscapes that usually match wi ...
2019Histone Modifications in Development and Malignancy
Non-Hodgkin lymphoma (NHL) development is driven by the accumulations of multiple genetic, epigenetic, and chromosomal alterations. These lesions can lead to modifications of the chromatin architecture. To identify novel oncogenic interactions driven by mo ...
AMER SOC HEMATOLOGY2019