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Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers

Related publications (42)

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Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates

Andrew Charles Oates

We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding elements (HCNEs), their develop ...

2007

Luminescent lanthanide bimetallic triple-stranded helicates as potential cellular imaging probes

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Steve Comby

Water-soluble triple-stranded [Ln2(L)3] helicates have been successfully tested as imaging probes in human cervical adenocarcinoma cells (HeLa), the complex being not toxic and clearly staining their cytoplasm in a concentrationdependent manner. ...

2007

Different modes of human papillomavirus DNA replication during maintenance

Peter Martin Beard

Human papillomavirus (HPV) begins its life cycle by infecting the basal cells of the epithelium. Within these proliferating cells, the viral genomes are replicated, maintained, and passed on to the daughter cells. Using HPV episome-containing cell lines th ...

2006

The human papillomavirus (HPV) E1 empty set E4 protein is the most abundantly expressed viral protein in HPV-infected epithelia. It possesses diverse activities, including the ability to bind to the cytokeratin network and to DEAD-box proteins, and in some ...

2004

Notch1 can contribute to viral-induced transformation of primary human keratinocytes

Peter Martin Beard

The human papillomavirus (HPV) is the most significant causative agent in the development of cervical cancer. Despite its presence in almost all cervical cancers, HPV by itself is unable to transform a normal cell to a cancerous one. Instead, additional ce ...

2003

Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNA

Peter Martin Beard

The human papillomavirus (HPV) E2 protein plays an important role in viral DNA replication. Many studies with high-risk HPVs have demonstrated that the E2 protein can also repress transcription of the E6 and E7 oncogenes. This conclusion, based on experime ...

2003

Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines

Cell-cell adhesion mediated by E-cadherin is often lost or disturbed in human carcinomas. For regular adhesive function, E-cadherin has to form complexes with peripheral cytoplasmic catenins which are multifunctional proteins that are also involved in sign ...

1997

Viral mRNAs from lesions containing human papillomavirus type 6 (HPV-6) have previously been mapped on the viral DNA but relatively little is known about the control of mRNA production, or whether the mapped RNA termini correspond to promoters. By analysis ...

1996

Papillomaviruses are believed to play an important role in the development of genital carcinoma. Herpes simplex virus (HSV) has been proposed as a cofactor. Here we show that HSV-1 interferes with the expression of human papillomavirus (HPV-18) genes in He ...

1993

A member of the activator protein 1 family found in keratinocytes but not in fibroblasts required for transcription from a human papillomavirus type 18 promoter

Peter Martin Beard

Papillomaviruses are tissue specific and replicate in differentiating keratinocytes. We are interested in the question of tissue specificity at the level of transcription. We used extracts from human keratinocytes and human fibroblasts at low passage numbe ...

1990