Suspension (topology)In topology, a branch of mathematics, the suspension of a topological space X is intuitively obtained by stretching X into a cylinder and then collapsing both end faces to points. One views X as "suspended" between these end points. The suspension of X is denoted by SX or susp(X). There is a variation of the suspension for pointed space, which is called the reduced suspension and denoted by ΣX. The "usual" suspension SX is sometimes called the unreduced suspension, unbased suspension, or free suspension of X, to distinguish it from ΣX.
Hepatic encephalopathyHepatic encephalopathy (HE) is an altered level of consciousness as a result of liver failure. Its onset may be gradual or sudden. Other symptoms may include movement problems, changes in mood, or changes in personality. In the advanced stages it can result in a coma. Hepatic encephalopathy can occur in those with acute or chronic liver disease. Episodes can be triggered by infections, GI bleeding, constipation, electrolyte problems, or certain medications.
Longitudinal studyA longitudinal study (or longitudinal survey, or panel study) is a research design that involves repeated observations of the same variables (e.g., people) over long periods of time (i.e., uses longitudinal data). It is often a type of observational study, although it can also be structured as longitudinal randomized experiment.
Framingham Heart StudyThe Framingham Heart Study is a long-term, ongoing cardiovascular cohort study of residents of the city of Framingham, Massachusetts. The study began in 1948 with 5,209 adult subjects from Framingham, and is now on its third generation of participants. Prior to the study almost nothing was known about the epidemiology of hypertensive or arteriosclerotic cardiovascular disease. Much of the now-common knowledge concerning heart disease, such as the effects of diet, exercise, and common medications such as aspirin, is based on this longitudinal study.
Car suspensionSuspension is the system of tires, tire air, springs, shock absorbers and linkages that connects a vehicle to its wheels and allows relative motion between the two. Suspension systems must support both road holding/handling and ride quality, which are at odds with each other. The tuning of suspensions involves finding the right compromise. It is important for the suspension to keep the road wheel in contact with the road surface as much as possible, because all the road or ground forces acting on the vehicle do so through the contact patches of the tires.
Air suspensionAir suspension is a type of vehicle suspension powered by an electric or engine-driven air pump or compressor. This compressor pumps the air into a flexible bellows, usually made from textile-reinforced rubber. Unlike hydropneumatic suspension, which offers many similar features, air suspension does not use pressurized liquid, but pressurized air. The air pressure inflates the bellows, and raises the chassis from the axle. Air suspension is used in place of conventional steel springs in heavy vehicle applications such as buses and trucks, and in some passenger cars.
Freudenthal suspension theoremIn mathematics, and specifically in the field of homotopy theory, the Freudenthal suspension theorem is the fundamental result leading to the concept of stabilization of homotopy groups and ultimately to stable homotopy theory. It explains the behavior of simultaneously taking suspensions and increasing the index of the homotopy groups of the space in question. It was proved in 1937 by Hans Freudenthal. The theorem is a corollary of the homotopy excision theorem. Let X be an n-connected pointed space (a pointed CW-complex or pointed simplicial set).
Acute liver failureAcute liver failure is the appearance of severe complications rapidly after the first signs (such as jaundice) of liver disease, and indicates that the liver has sustained severe damage (loss of function of 80–90% of liver cells). The complications are hepatic encephalopathy and impaired protein synthesis (as measured by the levels of serum albumin and the prothrombin time in the blood). The 1993 classification defines hyperacute as within 1 week, acute as 8–28 days, and subacute as 4–12 weeks; both the speed with which the disease develops and the underlying cause strongly affect outcomes.
Liver failureLiver failure is the inability of the liver to perform its normal synthetic and metabolic functions as part of normal physiology. Two forms are recognised, acute and chronic (cirrhosis). Recently, a third form of liver failure known as acute-on-chronic liver failure (ACLF) is increasingly being recognized. Acute liver failure Acute liver failure is defined as "the rapid development of hepatocellular dysfunction, specifically coagulopathy and mental status changes (encephalopathy) in a patient without known prior liver disease".
CirrhosisCirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is the impaired liver function caused by the formation of scar tissue known as fibrosis due to damage caused by liver disease. Damage to the liver leads to repair of liver tissue and subsequent formation of scar tissue. Over time, scar tissue can replace normal functioning tissue, leading to the impaired liver function of cirrhosis. The disease typically develops slowly over months or years.
