System for control of spasticity

The present invention relates to a neuromodulation/neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: - at least one control unit (12) configured and arranged to provide stimulation data, and - at least one stimulation unit (14), operatively connected to the at least one control unit (12), said at least one stimulation unit (14) being configured and arranged to deliver epidural electrical stimulation to the spinal cord of said mammal, according to said stimulation data, wherein the at least one stimulation unit (14) includes a biocompatible implantable lead (18) configured and arranged to cover at least a portion of the spinal cord of said mammal to deliver epidural electrical stimulation to the dorsal roots innervating the spastic muscles to target neuronal circuitry responsible for spastic episodes.

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Grégoire Courtine, Jocelyne Bloch, Robin Jonathan Demesmaeker, Fabien Bertrand Paul Wagner, Karen Minassian, Salif Axel Komi
2024
Patent

Abstract

Official source

https://infoscience.epfl.ch/record/311284?ln=en

About this result

Related concepts (20)

Related publications (34)

Neurostimulation

Neurostimulation is the purposeful modulation of the nervous system's activity using invasive (e.g. microelectrodes) or non-invasive means (e.g. transcranial magnetic stimulation or transcranial electric stimulation, tES, such as tDCS or transcranial alternating current stimulation, tACS). Neurostimulation usually refers to the electromagnetic approaches to neuromodulation.

Spinal cord stimulator

A spinal cord stimulator (SCS) or dorsal column stimulator (DCS) is a type of implantable neuromodulation device (sometimes called a "pain pacemaker") that is used to send electrical signals to select areas of the spinal cord (dorsal columns) for the treatment of certain pain conditions. SCS is a consideration for people who have a pain condition that has not responded to more conservative therapy. There are also spinal cord stimulators under research and development that could enable patients with spinal cord injury to walk again via epidural electrical stimulation (EES).

Spasticity

Spasticity () is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity, and hypertonia. It is also colloquially referred to as an unusual "tightness", stiffness, or "pull" of muscles. Clinically, spasticity results from the loss of inhibition of motor neurons, causing excessive velocity-dependent muscle contraction. This ultimately leads to hyperreflexia, an exaggerated deep tendon reflex. Spasticity is often treated with the drug baclofen, which acts as an agonist at GABA receptors, which are inhibitory.

Closed-Loop Control of Epidural Electrical Stimulation in Patients with Spinal Cord Injury and Parkinson's Disease

Nicolò Macellari

Over the past two decades, epidural electrical stimulation (EES) has transitioned from a treatment for chronic pain to a promising paradigm for ameliorating deficits associated with neurological disorders like spinal cord injury (SCI) and Parkinson's Disea ...

EPFL2023

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The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

2023

Walking naturally after spinal cord injury using a brain-spine interface

Grégoire Courtine, Jocelyne Bloch, Léonie Asboth, Robin Jonathan Demesmaeker, Anne Marie Lucienne Watrin, Sergio Daniel Hernandez, Henri Charles Alexandre Lorach, Jimmy James Ravier, Grégory Didier Dumont, Félix Antoine Martel, Laure Coquoz, Valeria Spagnolo, Thibault Jean Etienne Collin, Icare Sakr, Lucas Struber, Salif Axel Komi, Molywan Vat, Carmina Andrea Galvez Solano, Guillaume Vincent Charvet, Edeny Baaklini, Cathal John Harte, Olivier Pierre Nicolas Faivre, Serpil Karakas

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...

NATURE PORTFOLIO2023