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In vitro-transfusional model for red-blood-cell study: the advantage of lowering hematocrit
Related publications (38)
Hemoglobin-stabilized gold nanoclusters displaying oxygen transport ability, self-antioxidation, auto-fluorescence properties and long-term storage potential
The development of hemoglobin (Hb)-based oxygen carriers (HBOCs) holds a lot of potential to overcome important drawbacks of donor blood such as a short shelf life or the potential risk of infection. However, a crucial limitation of current HBOCs is the au ...
ROYAL SOC CHEMISTRY2023Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology
In this article, we describe the general features of red blood cell membranes and their effect on blood flow and blood rheology. We first present a basic description of membranes and move forward to red blood cell membranes' characteristics and modeling. W ...
MDPI2022Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules
Gerardo Turcatti, Benjamin Rappaz, David Crettaz, Michel Prudent, Manon Sandra Bardyn
An increase of oxygen saturation within blood bags and metabolic dysregulation occur during storage of red blood cells (RBCs). It leads to the gradual exhaustion of RBC antioxidant protective system and, consequently, to a deleterious state of oxidative s ...
2021Rhesus Blood Typing within a Few Seconds by Packing-Enhanced Nanoscattering on Individual Erythrocytes
Aleksandra Radenovic, Sebastian James Davis, Po-Ling Chang
A method for the ABO and Rhesus (Rh) blood group typing from individual erythrocytes is proposed in this study. Blood-group-specific antibodies immobilized to gold nanoparticles (BG-AuNP) were utilized for the identification of blood groups from individual ...
AMER CHEMICAL SOC2021In vitro investigations of red blood cell phase separation in a complex microchannel network
Microvascular networks feature a complex topology with multiple bifurcating vessels. Nonuniform partitioning (phase separation) of red blood cells (RBCs) occurs at diverging bifurcations, leading to a heterogeneous RBC distribution that ultimately affects ...
2020Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray Based Interferometric Point-of-Care Device
Hatice Altug, Filiz Yesilköy, Alexander Belushkin
Existing clinical methods for bacteria detection lack speed, sensitivity, and, importantly, point-of-care (PoC) applicability. Thus, finding ways to push the sensitivity of clinical PoC biosensing technologies is crucial. Here we report a portable PoC devi ...
AMER CHEMICAL SOC2019Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging
Gerardo Turcatti, Benjamin Rappaz, Pierre Marquet, Michel Prudent, Manon Sandra Bardyn
We propose methods to quantitatively calculate the fluctuation rate of red blood cells with nanometric axial and millisecond temporal sensitivity at the single-cell level by using time-lapse holographic cell imaging. For this quantitative analysis, cell me ...
OPTICAL SOC AMER2018Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy
Giovanni Dietler, Giovanni Longo, Francesco Simone Ruggeri
During their lifespan, Red blood cells (RBC), due to their inability to self-replicate, undergo an ageing degradation phenomenon. This pathway, both in vitro and in vivo, consists of a series of chemical and morphological modifications, which include devia ...
2018Cofactor sensing proteins for metabolic assays at point-of-care
Miniaturized blood analysis promises a substantial improvement for the process of healthcare. However, most current blood analysis methods were developed in the context of centralized laboratories and there is a lack of robust detection technologies suitab ...
EPFL2018Microdevice-integrated immunoassays for Point-of-Care Therapeutic Drug Monitoring
A significant number of drugs exhibit narrow therapeutic windows and high inter-individual pharmacokinetic variability. In such cases, Therapeutic Drug Monitoring (TDM) is compulsory in order to optimize the efficacy of the drug while avoiding adverse effe ...
EPFL2018