Development of a novel drug delivery system based on polymeric, thermoresponsive, hydrogel nanoparticles
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Gold nanoparticles coated with fluorinated ligands (F-MPCs) present features suitable for F-19 MRI as observed from phantom experiments. Cellular uptake, by HeLa cells, and toxicity of fluorescent dye-decorated F-MPCs are presented together with their abil ...
Grid turbulence of polyethylene oxide (PEO) solutions (Polyox WSR-301 in H2O) has been investigated experimentally for three concentrations of 25, 50 and 100 weight ppm, at a turbulence Reynolds number based on a Taylor microscale of Re-lambda approximate ...
Trigger happy: Trigger-responsive chain-shattering polymeric therapeutics (CSPTs) were prepared by condensation polymerization of a UV- or hydrogen peroxide-responsive domain and a drug as co-monomers. Drug release can be started and stopped by starting an ...
The fabrication of oxide-dispersion-strengthened (ODS) steels is a multi-stage process involving powder ball milling, degassing and consolidation by hot isostatic pressing. Y is introduced by mechanical alloying (MA) with either Y2O3 or Fe2Y so a high dens ...
The size of a nanomedicine strongly correlates with its biodistribution, tissue penetration, and cell uptake. However, there is limited understanding how the size of nanomedicine impacts the overall antitumor efficacy. We designed and synthesized camptothe ...
Gold nanoparticles are widely used in various applications in fields including chemistry, engineering, biology, medicine, and electronics. These materials can be synthesized and modified with ligands containing different functional groups. Among nanopartic ...
Gold nanoparticles modified with a two (or multi-) component polymer brush coating are an exciting class of nanomaterials. The presentation of two (or more) different polymer components can lead to truly multifaceted nanoparticles that can incorporate mult ...
Nanoscience is a young and growing field of science. It encompasses a diversity of sub-fields such as nanotechnology and nano-medicine, all of them seeking to realize the promises of nanoscale physics. Nano means: “billionth” and conceptually all nano-like ...
With a span as long as the history of polymer science itself, post-polymerization modification represents a versatile platform for the preparation of diversely functionalized polymers from a single precursor. Starting with the initial efforts by Staudinger ...
We developed camptothecin (CPT)-conjugated, core-cross-linked (CCL) micelles that are subject to redox-responsive cleavage of the built-in disulfide bonds, resulting in disruption of the micellar structure and rapid release of CPT. CCL micelles were prepar ...
