Stereoselective synthesis of 5a-ethyl-1,2,3,3a,4,5,5a,6,9a,9b-decahydro-1,3,4-trihydroxy-3a-(hydroxym ethyl)-7H-benz[e]inden-7-one derivatives
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Transition-metal catalysed enantioselective CâH functionalisations enable rapid increase of molecular complexity via non-classical disconnections. This thesis describes the development of intramolecular Pd(0)-catalysed C-H functionalisations for the asym ...
An enantioselective total synthesis of (-)-terengganensine A, a heptacyclic monoterpene indole alkaloid, was performed. A short sequence allowed to obtain the enantio-enriched target in good overall yield. The synthesis featured a key asymmetric transfer h ...
Alkene functionality can be found in the majority of natural products, drugs, catalysts and organic materials. Therefore, methods of C-C double bond formation constitute a cornerstone of organic synthesis. Selective formation of either (Z)- or (E)-isomer i ...
The cyclopentane scaffold has attracted much attention due to its ubiquity in numerous bioactive natural products such as prostaglandins and polyquinanes. However, despite a plethora of available procedures to access this motif, a lack of methods that riva ...
Organic chemistry is essential for the development of a modern society and technical progress requires the continuous development of synthetic methodologies Novel, efficient, selective and flexible protocols are employed to access complex frameworks from s ...
Asymmetric metal-catalyzed C-H functionalization is a powerful strategy for the rapid generation of complex target molecules from simple precursors. While aryl (pseudo) halides have been used as electrophilic substrates in enantioselective Pd(0)-catalyzed ...
Butene hydrogenation activity is intimately connected with the occupied and unoccupied electronic states of gold active site. We prepare well-defined Au(III) sites in IRMOF-3 structure, and tuned the metal density-of-states by replacing the substituent gro ...
Substantial signal enhancements achieved by using parahydrogen in catalytic hydrogenations are powerful tools for mechanistic studies of chemical reactions involving molecular H-2. Potentially, this technique can be extended to other reaction classes, prov ...
Pentamethylcyclopentadienyl (Cp*) based transition-metal-catalyzed C-H functionalization has become an important synthetic tool for the construction of molecular complexity from simple starting materials. Despite their high potential, the corresponding asy ...
Taddol-based phosphoramidite ligands enable enantioselective palladium(0)-catalyzed C-H arylation of cyclopropanes. The cyclized products are obtained in high yields and enantioselectivities. The reported method provides efficient access to a broad range o ...
