The Delivery of alpha 1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore

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Early Fate Choice Determines in vivo Engraftment and in vitro Behavior of Epidermal Stem Cells

François Gorostidi

Regenerative medicine aims at using stem cells to restore or establish lost, damaged, diseased, or aging tissues and organs function. The transplantation of cultured epidermal autograft (CEA) has saved the lives of many burned patients over the last 30 yea ...

EPFL2012

Real-time Full Field Laser Doppler Imaging

Theo Lasser, Marcel Leutenegger, Tyler Nerton Thacher

We present a full field laser Doppler imaging instrument that enables real-time in vivo assessment of blood flow in dermal tissue and skin. The instrument monitors the blood perfusion in an area of about 50cm2 with 480 x 480 pixels per frame at a rate of 1 ...

Amer Inst Physics2012

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

Friedrich Beermann, Simona Frateschi, Anne Wilson, Roch-Philippe Charles

Altered serine protease activity is associated with skin disorders in humans and in mice. The serine protease channel-activating protease-1 (CAP1; also termed protease serine S1 family member 8 (Prss8)) is important for epidermal homeostasis and is thus in ...

Nature Research2011

The Role of LEKTI in the Fate Determination of Keratinocyte Stem Cells

Alessandro Wataru Amici

SPINK5 (serine protease inhibitor Kazal-type 5) encodes the proteinase inhibitor LEKTI (lympho-epithelial Kazal-type related inhibitor). In skin, LEKTI expression is restricted to the stratum granulosum of the epidermis and the inner root sheath of hair fo ...

EPFL2011

Real-time full field laser Doppler imaging

Theo Lasser, Marcel Leutenegger, Antonio Lopez, Erica Martin-Williams, Tyler Nerton Thacher

We present a full field laser Doppler imaging instrument, which enables real-time in vivo assessment of blood flow in dermal tissue and skin. This instrument monitors the blood perfusion in an area of about 50 cm² with 480 × 480 pixels per frame at a rate ...

2011

Identification of epidermal pdx1 expression discloses different roles of notch1 and notch2 in murine kras-induced skin carcinogenesis in vivo

Freddy Radtke

BACKGROUND: The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis. To study the role of Notch and oncogenic Kras signaling in a progenitor ...

Public Library of Science2010

Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis

Friedrich Beermann

Summary We report on a systematic analysis of genotype-specific melanocyte UVR responses in transgenic mouse melanoma models along with tumour penetrance and comparative histopathology. pRb or p53 pathway mutations cooperated with Nras(Q61K) to transform m ...

2010

Key roles for transforming growth factor beta in melanocyte stem cell maintenance

Friedrich Beermann

Melanocyte stem cells in the bulge area of hair follicles are responsible for hair pigmentation, and defects in them cause hair graying. Here we describe the process of melanocyte stem cell entry into the quiescent state and show that niche-derived transfo ...

2010

Non-autoclave processing of honeycomb sandwich structures: Skin through thickness air permeability during cure

Véronique Michaud

In non-autoclave processing of sandwich structures, the pressure level inside the honeycomb becomes a critical process parameter, which depends on the permeability to air of the upper skin. In this work, prepreg and adhesive permeabilities were determined ...

Elsevier2010

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Identification of epidermal pdx1 expression discloses different roles of notch1 and notch2 in murine kras-induced skin carcinogenesis in vivo

Freddy Radtke

Public Library of Science2010