SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

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Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Johan Auwerx, Xiaoxu Li, Maroun Bou Sleiman, Jun Yong Kim

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial ro ...

Nature Portfolio2023

DIET Controller: Dynamic Indoor Environment using Deep Reinforcement Learning

Arnab Chatterjee

Heating, Ventilation, and Air Conditioning (HVAC) Systems utilize much energy, accounting for 40% of total building energy use. The temperatures in buildings are commonly held within narrow limits, leading to higher energy use. Measurements from office bui ...

EPFL2023

Improved Waste Heat Management and Energy Integration in an Aluminum Annealing Continuous Furnace Using a Machine Learning Approach

François Maréchal, Daniel Alexander Florez Orrego, Réginald Germanier, Mohammad Andayesh, Manuele Gatti

Annealing furnaces are critical for achieving the desired material properties in the production of high-quality aluminum products. In addition, energy efficiency has become more and more important in industrial processes due to increasing decarbonization r ...

2023

A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function

Pernille Yde Rainer

White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as a reservoir for storing and releasing energy but also actively participates in metabolic homeostasis. Given the current rise in obesity and its associated como ...

EPFL2023

Cross-anatomical single-cell definition and characterization of human adipose progenitor niche

Radiana Ferrero

Adipose tissue is a key metabolic and highly-dynamic organ whose dysregulation may cause clinical conditions of concern such as obesity and lipodystrophy. Its function varies based on the anatomy, in fact, visceral adipose tissue expansion carries a greate ...

EPFL2023

ROSMOSE: A Web-based Optimization Tool to Aid Decision-making for the Design and Operation of Industrial and Urban Energy Systems

François Maréchal, Daniel Alexander Florez Orrego, Meire Ellen Gorete Ribeiro Domingos, Cédric Terrier, Michel Lopez

Energy efficiency is crucial for the sustainable operation of all industrial and urban sectors. However, practicing engineers have seldom access to open-source tools that can readily evaluate and compare scenarios in terms of energy consumption, cost, and ...

2023

Renewable Energy Integration and Waste Heat Recovery for the Production of Sustainable Jet Fuel and Decarbonization of Industrial Heating Applications

François Maréchal, Daniel Alexander Florez Orrego, Meire Ellen Gorete Ribeiro Domingos, Réginald Germanier

The process synthesis and optimization methods used in this work include simulation of biomass gasification, hydrogen and synthetic natural gas production, and jet fuel production via a Fisher Tropsch unit. An energy integration approach, carried out by th ...

American Institute of Chemical Engineering2023

A modelling framework for modern heritage buildings energy simulation

Franz Graf, Giulia Marino, Giuseppe Galbiati

The latest European polices highlight the urgent need to rehabilitate the existing building stock, responsible for 40 % of the EU's total energy consumption. In this process, a key role is played by thermal simulations, assessing the effective energy perfo ...

Elsevier2023

A systemic study for enhanced waste heat recovery and renewable energy integration towards decarbonizing the aluminium industry

François Maréchal, Daniel Alexander Florez Orrego, Réginald Germanier

The aluminium remelting industry relies on natural gas to transform recycled aluminium into aluminium feedstock, entailing significant atmospheric emissions. Hydric resources are also affected as they are used as sinks of waste heat from the casting proces ...

2023

Small-scale turbopumps for waste heat recovery applications based on an organic Rankine cycle: a study from pre-design to experimental validation

Sajjad Zakeralhoseini

The organic Rankine cycle (ORC) system is among the technologies applied to exploit waste heat in vehicles. Since common organic fluids have lower latent heat than water, higher mass flow rates are required to convert the same waste heat, considerably incr ...

EPFL2023

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