Publications related to Chemical approaches to microarrays and multifunctional protein labeling

Recording physiological history of cells with chemical labeling

Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular events for later analysis. We designed proteins t ...

Amer Assoc Advancement Science2024

New protein–protein interactions designed by a computer

Pablo Gainza Cirauqui, Anthony Marchand

Creating protein interactions through computational design is a key challenge in the fields of both basic and translational biology. An approach that uses the machine-learned fingerprints of protein-surface features was used to produce synthetic proteins t ...

2023

Difference in astringency of the main pea protein fractions

Francesco Stellacci, Hanna Fanny Clarisse Lesme

Interactions between food and saliva govern complex mouthfeel perceptions such as astringency. Herein, we present a study of the interactions of salivary proteins with the main pea protein fractions that are obtained by isoelectric and salt precipitation ( ...

London2023

Azide-Containing Hypervalent Iodine Reagents for Biomolecules Functionalization

Raphaël Michel Henri Simonet-Davin

The goal of my PhD was the development of a new method for unselective surface labeling, not substrate-specific, that would give access to direct visualization of any surface interactions.In order to achieve this challenging goal, we wanted to develop a ge ...

EPFL2022

Keap 1: The new Janus word on the block

Yimon Aye

Here we draw insights from the latest serendipitous findings made on the opposing roles of a proposed drug-target protein Keap1. We weigh up how natural reactive electrophiles and electrophilic small-molecule drugs in clinical use directly impinge on seemi ...

PERGAMON-ELSEVIER SCIENCE LTD2022

David Lyndon Emsley, Jayasubba Reddy Yarava, Andrea Bertarello, Baptiste Busi, François Freymond

Understanding and describing the dynamics of proteins is one of the major challenges in biology. Here, we use multifield variable-temperature NMR longitudinal relaxation (R-1) measurements to determine the hierarchical activation energies of motions of fou ...

AMER CHEMICAL SOC2021

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

Bruno Emanuel Ferreira De Sousa Correia, Zander Harteveld, Julius Valten Upmeier Zu Belzen

Optogenetic control of CRISPR-Cas9 systems has significantly improved our ability to perform genome perturbations in living cells with high precision in time and space. As new Cas orthologues with advantageous properties are rapidly being discovered and en ...

2021

Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities

Yimon Aye, Yi Zhao

Transient associations between numerous organelles-e.g., the endoplasmic reticulum and the mitochondria-forge highly-coordinated, particular environments essential for cross-compartment information flow. Our perspective summarizes chemical-biology tools th ...

ROYAL SOC CHEMISTRY2020

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Chemical approaches to microarrays and multifunctional protein labeling

Recording physiological history of cells with chemical labeling

New protein–protein interactions designed by a computer

Difference in astringency of the main pea protein fractions

Towards automating de novo protein design for novel functionalities: controlling protein folds and protein-protein interactions

Azide-Containing Hypervalent Iodine Reagents for Biomolecules Functionalization

Keap 1: The new Janus word on the block

Similarities and Differences among Protein Dynamics Studied by Variable Temperature Nuclear Magnetic Resonance Relaxation

FIB-milled plasmonic nanoapertures allow for long trapping times of individual proteins

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities

Graph Chatbot

Chat with Graph Search

Difference in astringency of the main pea protein fractions

Recording physiological history of cells with chemical labeling

Similarities and Differences among Protein Dynamics Studied by Variable Temperature Nuclear Magnetic Resonance Relaxation

Towards automating de novo protein design for novel functionalities: controlling protein folds and protein-protein interactions

New protein–protein interactions designed by a computer

FIB-milled plasmonic nanoapertures allow for long trapping times of individual proteins

Azide-Containing Hypervalent Iodine Reagents for Biomolecules Functionalization

Keap 1: The new Janus word on the block

Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein