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Novel reactive perstraction system applied to the hydrolysis of penicillin G
Related publications (43)
Enzyme and Acid Deconjugation of Plasma Sulfated Metanephrines
Background: Total (i.e. free + sulfated) metanephrines in plasma is a biomarker for the diagnosis of pheochromocytoma/paraganglioma. Sulfated metanephrines must be completely deconjugated by perchloric acid hydrolysis or sulfatase treatment prior to analyt ...
Elsevier2014[Fe]-hydrogenase and Models Containing An Iron-Acyl Ligation
[Fe]-hydrogenase is a newly characterized type of hydrogenase. This enzyme heterolytically splits hydrogen in the presence of a natural substrate. The active site of the enzyme contains a mono-iron complex with intriguing ironacyl ligation. Several groups ...
Wiley-V C H Verlag Gmbh2013The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis
The re-emergence of tuberculosis in recent years led the World Health Organization (WHO) to launch the Stop TB Strategy program. Beside repurposing the existing drugs and exploring novel molecular combinations, an essential step to face the burden of tuber ...
Springer2013A new target for gold(I) compounds: glutathione-S.transferase inhibition by auranofin
Paul Joseph Dyson, Christian Hartinger, Angela Casini
Nowadays, gold compounds occupy a relevant position constituting a promising class of experimental anticancer metallodrugs. Several research efforts have been devoted to the investigations of the pharmacological properties of gold(I) complexes bearing phos ...
Elsevier Science Inc2013Role of Environment for Catalysis of the DNA Repair Enzyme MutY
Ursula Röthlisberger, Jeremy Samuel Arey, Elizabeth Claire Brunk
Control of the N-glycosylase reaction by the DNA repair enzyme, MutY, entails the organization of solvent molecules. Classical molecular dynamics and QM/MM simulations were used to investigate the solvent and environment effects contributing to catalysis. ...
2012Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-
Stewart Cole, Kai Johnsson, Florence Pojer, Claudia Trefzer
Benzothiazinones (BTZs) are antituberculosis drug candidates with nanomolar bactericidal activity against tubercle bacilli. Here we demonstrate that BTZs are suicide substrates of the FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1, ...
2012Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation
Paul Joseph Dyson, Ursula Röthlisberger, Wee Han Ang, Pablo Campomanes Ramos
Platinum-based cancer drugs, such as cisplatin, are highly effective chemotherapeutic agents used extensively for the treatment of solid tumors. However, their effectiveness is limited by drug resistance, which, in some cancers, has been associated with an ...
Wiley-Blackwell2011A novel enzyme entrapment in SU-8 microfabricated films for glucose micro-biosensors
The present work investigates the utilisation of the widely used SU-8 photoresist as an immobilisation matrix for glucose oxidase (GOx) for the development of glucose micro-biosensors. The strong advantage of the proposed approach is the simultaneous enzym ...
Elsevier2010