Fabrication of a Millinewton Force Sensor Using Low Temperature Co-fired Ceramic (LTCC) Technology
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Contamination of drinking water with arsenic is a recurring problem in both industrialized and developing countries. Supplies for large populations can have concentrations much higher than the permissible levels, set by the World Health Organization (WHO) ...
Protein acetylation, which is central to transcriptional control as well as other cellular processes, is disrupted in Huntington's disease (HD). Treatments that restore global acetylation levels, such as inhibiting histone deacetylases (HDACs), are effecti ...
Bicyclic peptides binding to targets of interest can be isolated from combinatorial libraries using a phage display-based approach. In a first project of this thesis, we aimed at generating bicyclic peptide inhibitors of matrix metalloproteinases (MMPs), a ...
EPFL2012
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The molecular structures and electronic and optical properties of 2,2'7,7'-tetrakis-(N,N-di-p-methoxyphenyl amine)-9,9'-spirobifluorene (spiro-MeOTAD) in different oxidation states have been investigated by means of DFT/TDDFT methods. Spiro-MeOTAD has been ...
The periodontal ligament (PDL) is a highly vascularized soft connective tissue. Previous studies suggest that the viscous component of the mechanical response may be explained by the deformation-induced collapse and expansion of internal voids (i.e. chiefl ...
Mammalian cells in bioreactors as production host are the focus of this review. We wish to briefly describe today's technical status and to highlight emerging trends in the manufacture of recombinant therapeutic proteins, focusing on Chinese hamster ovary ...
Efficient access to proteins modified site-specifically with glycans is important in glycobiology and for therapeutic applications. Herein, we report a biocompatible protein glycoconjugation by inverse demand Diels-Alder reaction between tetrazine and tran ...
Soft, bioelectronics interfaces are broadly defined as microfabricated devices with mechanical properties suited to comply with biological tissues. There are many challenges associated with the development of such technology platforms. Simultaneously one m ...
Spie-Int Soc Optical Engineering2014
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The development of novel therapies against neurodegenerative disorders requires the ability to detect their early, presymptomatic manifestations in order to enable treatment before irreversible cellular damage occurs. Precocious signs indicative of neurode ...
A fine control of a photonic molecule is obtained by nanofluidic techniques. The coupling condition between the modes of two photonic crystal nanocavities is modified by spectrally tuning each single resonator. Clear mode anticrossing and transition from l ...