Publications related to Nuclear envelope: torn apart at mitosis

Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes

Centrosome separation along the surface of the nucleus at the onset of mitosis is critical for bipolar spindle assembly. Dynein anchored on the nuclear envelope is known to be important for centrosome separation, but it is unclear how nuclear dynein forces ...

Amer Soc Cell Biology2017

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Pierre Gönczy, Alessandro De Simone

The two centrosomes present at the onset of mitosis must separate in a timely and accurate fashion to ensure proper bipolar spindle assembly. The minus-end-directed motor dynein plays a pivotal role in centrosome separation, but the underlying mechanisms r ...

Elsevier2016

Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

Pierre Gönczy, Coralie Busso, Sachin Kotak

Accurate spindle positioning is essential for error-free cell division. The one-cell Caenorhabditis elegans embryo has proven instrumental for dissecting mechanisms governing spindle positioning. Despite important progress, how the cortical forces that act ...

2016

Importin-beta modulates the permeability of the nuclear pore complex in a Ran-dependent manner

Michael Graf

Soluble karyopherins of the importin-beta (imp beta) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether imp beta or RanGTP regulate the permeability of the NPC itself has been unknown. In this study, we iden ...

Elife Sciences Publications Ltd2015

NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

Pierre Gönczy, Coralie Busso, Sachin Kotak

The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gai1-3 anchor the coiled-coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper s ...

2014

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Graham Knott, Liliane Glauser, Elpida Tsika, Darren Moore, Shi-Yan Caroline Foo, Meghna Kannan

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). The clinical and neurochemical features of LRRK2-linked PD are similar to idiopathic disease although neuropathology is somewhat heter ...

Elsevier2014

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

Pierre Gönczy, Coralie Busso, Sachin Kotak

Spindle positioning and spindle elongation are critical for proper cell division. In human cells, an evolutionary conserved ternary complex (NuMA/LGN/Gαi) anchors dynein at the cortex during metaphase, thus ensuring correct spindle positioning. Whether thi ...

Nature Publishing Group2013

The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos

Pierre Gönczy, Coralie Busso

Regulation of mitosis in time and space is critical for proper cell division. We conducted an RNA interference-based modifier screen to identify novel regulators of mitosis in Caenorhabditis elegans embryos. Of particular interest, this screen revealed tha ...

Amer Soc Cell Biology2012

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Nuclear envelope: torn apart at mitosis

Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes

Mechanisms of centrosome separation in C. elegans

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

Importin-beta modulates the permeability of the nuclear pore complex in a Ran-dependent manner

NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

Selective transport control on molecular velcro made from intrinsically disordered proteins

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos

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Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

Importin-beta modulates the permeability of the nuclear pore complex in a Ran-dependent manner

Mechanisms of centrosome separation in C. elegans

Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos

Selective transport control on molecular velcro made from intrinsically disordered proteins

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane