A formal total synthesis of the marine alkaloid aaptamine

A new strategy for the synthesis of benzo[de][1,6]naphthyridine derivative 2,3,3a,4,5,6-hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2,3,3a,4,5,6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural product. (c) 2008 Elsevier Ltd. All rights reserved.

A formal total synthesis of the marine alkaloid aaptamine

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Synthesis and Applications of Ynimines and Enantioselective Total Synthesis of Artatrovirenol A

Organic Chemistry and Synthesis Rely More and More upon Catalysts

Natural Product Synthesis Enabled by Domino Processes Incorporating a 1,2-Rearrangement Step

Synthesis and Applications of Ynimines and Enantioselective Total Synthesis of Artatrovirenol A

Organic Chemistry and Synthesis Rely More and More upon Catalysts

Natural Product Synthesis Enabled by Domino Processes Incorporating a 1,2-Rearrangement Step