Hippocampal up-regulation of NCAM expression and polysialylation plays a key role on spatial memory
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We examined the expression of genes related to brain energy metabolism and particularly those encoding glia (astrocyte)-specific functions in the dorsal hippocampus subsequent to learning. Context-dependent avoidance behavior was tested in mice using the s ...
Neurons utilize mitochondrial oxidative phosphorylation (OxPhos) to generate energy essential for survival, function, and behavioral output. Unlike most cells that burn both fat and sugar, neurons only burn sugar. Despite its importance, how neurons meet t ...
Cell Press2015
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Synaptic plasticity, a key process for memory formation, manifests itself across different time scales ranging from a few seconds for plasticity induction up to hours or even years for consolidation and memory retention. We developed a three-layered model ...
Yona Friedman is recognized as one of the most eminent proponents of 1960s avant-garde urbanism. His best-known work is the concept for a Spatial City (“La Ville Spatiale”, 1956), in which he aimed to provide maximum flexibility through “megastructures” ov ...
The heterogeneity of the subfossil chironomid deposition (in terms of assemblages and paleo-diet) has to be studied to assess the reliability of paleolimnological interpretations (i.e., spatial representativeness). We collected 31 cores in the deepest part ...
Nectins are cell adhesion molecules that are widely expressed in the brain. Nectin expression shows a dynamic spatiotemporal regulation, playing a role in neural migratory processes during development. Nectin-1 and nectin-3 and their heterophilic trans-int ...
Awareness, focused attention, and task-relevance were thought to be necessary for perceptual learning (PL): a Feature of the Stimulus (FoS) on which participants perform a task is learned, while a task-irrelevant FoS is not learned. This view has been chal ...
Sage Publications Ltd2016
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Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL) from ...
The brain has very high energy demands that are mainly met by the circulating blood glucose to ensure its proper functioning. Thus, it is not surprising that though the human brain weighs only 2- 3% of the body weight, it consumes approximately 25% of tota ...
The hippocampal dentate gyrus (DG) is one of the two sites where neurogenesis continues throughout life in the mammalian brain. Accumulating evidence suggests a unique contribution of adult-generated dentate neurons in hippocampal synaptic plasticity and h ...