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Enhanced Plasmid DNA Utilization in Transiently Transfected CHO-DG44 Cells in the Presence of Polar Solvents

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The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely structure-based design methods limited their application, but recent strategies that combine structure-based and sequence-based calcu ...

Nature Portfolio2024

Development of tools and methods for protein identification: From single molecules to in vivo applications

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As the fundamental machinery orchestrating cellular functions, proteins influence the state of every cell profoundly. As cells exhibit significant variations from one to another, analyzing the proteome on a single-cell level is imperative to unravel their ...

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Development of cysteine cathepsin inhibitors combined with cell type-specific delivery for the treatment of B-cell lymphoma and solid tumors

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Cysteine cathepsins proteases are enzymes that play essential physiological roles, but their activity is also associated to different aspects of cancer progression and to the development of other diseases. Therefore, cysteine cathepsins are relevant and pr ...

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Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

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Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology, autoimmune disorders, and viral infections. However, the wide application of such protein therapeut ...

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Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release

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Royal Soc Chemistry2023

De novo designed proteins: a study in engineering novel folds and functions

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Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

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Proteins are the basic building blocks necessary for the operation and regulation of virtually all functions in living organisms. Over millions of years, evolution has created a vast repertoire of proteins finely tuned to execute their biological functions ...

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Natural competence of the pathogen Acinetobacter baumannii: an elusive phenomenon

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Natural competence for transformation is an important driver of horizontal DNA exchange between different organisms. This can result in accumulation of dangerous genetic features, such as antibiotic resistance genes, in a single organism. One example of an ...

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Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody

Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard

COVID-19 is caused by the infection of the lungs by SARS-CoV-2. Monoclonal antibodies, such as sotrovimab, showed great efficiency in neutralizing the virus before its internalization by lung epithelial cells. However, parenteral routes are still the prefe ...

2023

Enhanced Plasmid DNA Utilization in Transiently Transfected CHO-DG44 Cells in the Presence of Polar Solvents

Opportunities and challenges in design and optimization of protein function

Development of tools and methods for protein identification: From single molecules to in vivo applications

Development of cysteine cathepsin inhibitors combined with cell type-specific delivery for the treatment of B-cell lymphoma and solid tumors

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release

De novo designed proteins: a study in engineering novel folds and functions

Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors

Natural competence of the pathogen Acinetobacter baumannii: an elusive phenomenon

Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody

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Opportunities and challenges in design and optimization of protein function

Development of tools and methods for protein identification: From single molecules to in vivo applications

Development of cysteine cathepsin inhibitors combined with cell type-specific delivery for the treatment of B-cell lymphoma and solid tumors

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release

Design of an artificial phage-display library based on a new scaffold improved for average stability of the randomized proteins

De novo designed proteins: a study in engineering novel folds and functions

Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors

Natural competence of the pathogen Acinetobacter baumannii: an elusive phenomenon

Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody

Design of an artificial phage-display library based on a new scaffold improved for average stability of the randomized proteins