Opportunities for Targeting the Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Receptor Pathway in Hypertension

Related publications (28)

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

Rationale: Hypertension represents a major risk factor for stroke, myocardial infarction, and heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to hypertension, but specific mechanisms are unclear. The mitochondri ...

2020

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Younouss Faye

IntroductionAngiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development ...

Wiley-Blackwell2015

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Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

Johan Auwerx

2020

Hemodynamics of ageing, ventricular-arterial coupling and noninvasive assessment of key hemodynamical and cardiac quantities

Stamatia Zoi Pagoulatou

Ageing is a natural process that affects both the anatomical and functional properties of the cardiovascular system and alters the coupling characteristics between the heart and the aorta. These alterations may predispose the cardiovascular system in the d ...

EPFL2020

Hypericin can cross barriers in the chicken's chorioallantoic membrane model when delivered in low-density lipoproteins

Georges Wagnières, Veronika Huntosova

Background: Low-density lipoproteins (LDL) were used as a natural drug delivery system for the transport of hypericin (Hyp) in the bloodstream of the chicken's chorioallantoic membrane model (CAM). Hyp was chosen as a model for hydrophobic drug used in pho ...

ELSEVIER SCIENCE BV2018

Non-invasive hemodynamic monitoring by electrical impedance tomography

Martin Proença

The monitoring of central hemodynamic parameters such as cardiac output (CO) and pulmonary artery pressure (PAP) is of paramount clinical importance to assess the health status of the cardiovascular system. However, their measurement requires the insertion ...

EPFL2017

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Younouss Faye

Wiley-Blackwell2015

Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches

Vassily Hatzimanikatis, Ljubisa Miskovic, Aikaterini Zisaki

Drug discovery and development is a high-risk enterprise that requires significant investments in capital, time and scientific expertise. The studies of xenobiotic metabolism remain as one of the main topics in the research and development of drugs, cosmet ...

Bentham Science Publishers2015

Total arterial compliance estimated by a novel method and all-cause mortality in the elderly: the PROTEGER study

Nikolaos Stergiopoulos, Orestis Vardoulis

Aortic stiffness, assessed by carotid-to-femoral pulse wave velocity (PWV), often fails to predict cardiovascular (CV) risk and mortality in the very elderly. This may be due to the non-linear association between PWV and compliance or to blood pressure dec ...

Springer Verlag2014

Pathophysiological role of the renin-angiotensin system on erectile dysfunction

Nikolaos Stergiopoulos

Background The renin-angiotensin system (RAS) has been shown to play an active role within the erectile tissues. The aim of this narrative review is to summarize the literature addressing the pathophysiological role of RAS on erectile function. Additionall ...

Wiley-Blackwell2013

Role of the renin-angiotensin system on abdominal aortic aneurysms

Nikolaos Stergiopoulos, Bram Trachet

BackgroundAbdominal aortic aneurysm (AAA) is a complex degenerative disease, which leads to morbidity and mortality in a large portion of the elderly population. Current treatment options for AAA are quite limited as there is no proven indication for pharm ...

Wiley-Blackwell2013

An Oral Formulation of Angiotensin-(1-7) Reverses Corpus Cavernosum Damages Induced by Hypercholesterolemia

Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Danielle Gomes Passos Silva

Introduction The renin angiotensin system plays a crucial role in erectile function. It has been shown that elevated angiotensin-II levels contribute to the development of erectile dysfunction (ED). Oppositely, angiotensin-(1-7) (Ang-[1-7]) mediates penile ...

Wiley-Blackwell2013

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Hemodynamics of ageing, ventricular-arterial coupling and noninvasive assessment of key hemodynamical and cardiac quantities

Stamatia Zoi Pagoulatou

EPFL2020