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Microsecond time-resolved cryo-electron microscopy

Related publications (30)

Computer-implemented design of peptide:receptor signaling complexes for enhanced chemotaxis

Patrick Daniel Barth, Robert Everett Jefferson

The present invention relates to a computer-implemented method for engineering the interaction between a protein and a cognate peptide that are capable of forming a molecular complex, wherein the method comprises (a) preparing in silico a library of test p ...

2023

Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis

Patrick Daniel Barth, Aurélien Laurent Jean-Charles Oggier, Ana Paola Rico Villarreal, Mahdi Hijazi, Robert Everett Jefferson, Andreas Füglistaler

Engineering protein biosensors that sensitively respond to specific biomolecules by triggering precise cellular responses is a major goal of diagnostics and synthetic cell biology. Previous biosensor designs have largely relied on binding structurally well ...

Nature Research2023

De novo designed proteins: a study in engineering novel folds and functions

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Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

EPFL2023

Generative power of a protein language model trained on multiple sequence alignments

Anne-Florence Raphaëlle Bitbol, Umberto Lupo, Damiano Sgarbossa

Computational models starting from large ensembles of evolutionarily related protein sequences capture a representation of protein families and learn constraints associated to protein structure and function. They thus open the possibility for generating no ...

eLIFE SCIENCES PUBL LTD2023

De novo design of protein interactions with learned surface fingerprints

Didier Trono, Henning Paul-Julius Stahlberg, Beat Fierz, Priscilla Turelli, Bruno Emanuel Ferreira De Sousa Correia, Elisa Oricchio, Sandrine Madeleine Suzanne Georgeon, Dongchun Ni, Andreas Scheck, Michael Bronstein

Physical interactions between proteins are essential for most biological processes governing life. However, the molecular determinants of such interactions have been challenging to understand, even as genomic, proteomic and structural data increase. This k ...

2023

Antenna-coupled infrared nanospectroscopy of intramolecular vibrational interaction

Hatice Altug, Aurélian Michel John-Herpin, Felipe Herrera

Many photonic and electronic molecular properties, as well as chemical and biochemical reactivities are controlled by fast intramolecular vibrational energy redistribution (IVR). This fundamental ultrafast process limits coherence time in applications from ...

National Academy of Sciences2023

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

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Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology, autoimmune disorders, and viral infections. However, the wide application of such protein therapeut ...

2023

Advancing first principle-based molecular dynamics of biological systems with machine learning

François Louis Mouvet

Molecular dynamics (MD) simulations have emerged as a transformative approach to analyse molecular systems at the atomic level, offering valuable insights into complex biological processes. Many biological phenomena can only accurately be described by inco ...

EPFL2023

A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers

Christoph Bostedt, Camila Bacellar Cases Da Silveira

Serial crystallography at X-ray free-electron lasers (XFELs) permits the determination of radiation-damage free static as well as time-resolved protein structures at room temperature. Efficient sample delivery is a key factor for such experiments. Here, we ...

Nature Portfolio2023

Microsecond time-resolved cryo-electron microscopy

Computer-implemented design of peptide:receptor signaling complexes for enhanced chemotaxis

Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis

De novo designed proteins: a study in engineering novel folds and functions

Generative power of a protein language model trained on multiple sequence alignments

De novo design of protein interactions with learned surface fingerprints

Antenna-coupled infrared nanospectroscopy of intramolecular vibrational interaction

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

Advancing first principle-based molecular dynamics of biological systems with machine learning

A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers

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Computer-implemented design of peptide:receptor signaling complexes for enhanced chemotaxis

Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis

De novo designed proteins: a study in engineering novel folds and functions

Generative power of a protein language model trained on multiple sequence alignments

De novo protein design by inversion of the AlphaFold structure prediction network

De novo design of protein interactions with learned surface fingerprints

Antenna-coupled infrared nanospectroscopy of intramolecular vibrational interaction

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

Advancing first principle-based molecular dynamics of biological systems with machine learning

A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers

De novo protein design by inversion of the AlphaFold structure prediction network