Protein foldingProtein folding is the physical process where a protein chain is translated into its native three-dimensional structure, typically a "folded" conformation, by which the protein becomes biologically functional. Via an expeditious and reproducible process, a polypeptide folds into its characteristic three-dimensional structure from a random coil. Each protein exists first as an unfolded polypeptide or random coil after being translated from a sequence of mRNA into a linear chain of amino acids.
Phospholipid scramblaseScramblase is a protein responsible for the translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane. In humans, phospholipid scramblases (PLSCRs) constitute a family of five homologous proteins that are named as hPLSCR1–hPLSCR5. Scramblases are not members of the general family of transmembrane lipid transporters known as flippases. Scramblases are distinct from flippases and floppases. Scramblases, flippases, and floppases are three different types of enzymatic groups of phospholipid transportation enzymes.
Projective moduleIn mathematics, particularly in algebra, the class of projective modules enlarges the class of free modules (that is, modules with basis vectors) over a ring, by keeping some of the main properties of free modules. Various equivalent characterizations of these modules appear below. Every free module is a projective module, but the converse fails to hold over some rings, such as Dedekind rings that are not principal ideal domains.
Head and neck cancerHead and neck cancer develops from tissues in the lip and oral cavity (mouth), larynx (throat), salivary glands, nose, sinuses, or skin of the face. The most common types of head and neck cancer occur in the lips, mouth, and larynx. Symptoms predominantly include a sore that does not heal or a change in the voice. In those with advanced disease, there may be unusual bleeding, facial pain, numbness or swelling, and visible lumps on the outside of the neck or oral cavity.
Localization (commutative algebra)In commutative algebra and algebraic geometry, localization is a formal way to introduce the "denominators" to a given ring or module. That is, it introduces a new ring/module out of an existing ring/module R, so that it consists of fractions such that the denominator s belongs to a given subset S of R. If S is the set of the non-zero elements of an integral domain, then the localization is the field of fractions: this case generalizes the construction of the field of rational numbers from the ring of integers.
Flat moduleIn algebra, flat modules include free modules, projective modules, and, over a principal ideal domain, torsion free modules. Formally, a module M over a ring R is flat if taking the tensor product over R with M preserves exact sequences. A module is faithfully flat if taking the tensor product with a sequence produces an exact sequence if and only if the original sequence is exact. Flatness was introduced by in his paper Géometrie Algébrique et Géométrie Analytique.
BiomarkerIn biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues to examine normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Biomarkers are used in many scientific fields. Biomarker (medicine)Biomarkers used in the medical field, are a part of a relatively new clinical toolset categorized by their clinical applications.
Protein purificationProtein purification is a series of processes intended to isolate one or a few proteins from a complex mixture, usually cells, tissues or whole organisms. Protein purification is vital for the specification of the function, structure and interactions of the protein of interest. The purification process may separate the protein and non-protein parts of the mixture, and finally separate the desired protein from all other proteins.
ProteomicsProteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body. The proteome is the entire set of proteins produced or modified by an organism or system.
HepatectomyHepatectomy is the surgical resection (removal of all or part) of the liver. While the term is often employed for the removal of the liver from a liver transplant donor, this article will focus on partial resections of hepatic tissue and hepatoportoenterostomy. The first hepatectomies were reported by Dr. Ichio Honjo (1913–1987) of (Kyoto University) in 1949, and Dr. Jean-Louis Lortat-Jacob (1908–1992) of France in 1952. In the latter case, the patient was a 58-year-old woman diagnosed with colorectal cancer which had metastasized to the liver.
