Unit

Prof. Barth Group

Laboratory
Summary

The Laboratory of Protein and Cell Engineering at EPFL focuses on the interdisciplinary research areas of computational biology, protein design, and therapeutic systems cell engineering. They work on designing protein systems with novel biosensing and signaling functions for synthetic biology applications, predicting the effects of genetic variations on protein structure for personalized cancer medicine, and rewiring signaling pathways in engineered immune cells to improve cancer immunotherapies. Their computational techniques accurately model and design membrane protein structures and interactions with small molecules, aiming to expand the number of engineered membrane proteins and targeted drug design strategies.

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Related publications (34)

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Mahdi Hijazi

The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...
EPFL2024

Computational rewiring of allosteric pathways reprograms GPCR selective responses to ligands

Patrick Daniel Barth, Mahdi Hijazi, Aurélien Laurent Jean-Charles Oggier, Dániel Kéri

G-protein-coupled receptors (GPCRs) are the largest class of cell surface receptors and drug targets, and respond to a wide variety of chemical stimuli to activate diverse cellular functions. Understanding and predicting how ligand binding triggers a speci ...
bioRxiv2022

Computationally designed GPCR quaternary structures bias signaling pathway activation

Patrick Daniel Barth, Robert Everett Jefferson

Communication across membranes controls critical cellular processes and is achieved by receptors translating extracellular signals into selective cytoplasmic responses. While receptor tertiary structures can be readily characterized, receptor associations ...
2022
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