by Prof. Suter

The Laboratory by Prof. Suter, known as UPSUTER, focuses on studying the regulation of cell identity using quantitative, time-resolved approaches that span the entire gene expression flow. They combine molecular cell biology, computational, and biophysical expertise to investigate gene regulation during mitotic exit, fluctuations in transcription factor levels affecting cell fate decisions, and transcription factor search dynamics. The lab uses genome editing and various imaging modalities to quantify transcription factor motions, mRNA production, protein synthesis, and degradation in single live cells. They also employ high throughput genomics technologies for studying both physiological and pathological regulation of cell identity, with a particular focus on embryonic stem cells and cancer cells.