Catégorie

Médecine de soins critiques

Publications associées (426)

Predicting Acute Hypotensive Episodes

Jean-Marc Vesin, Mathieu Lemay, Florian Jousset

The goal of the challenge 2009 is to predict which patients will experience acute hypotensive episode (AHE) within a forecast window. AHE may result in dangerous complications and even death. Predicting the onset of AHE would be of clear benefit to a patie ...

2009

Intercellular calcium dynamics in smooth muscle cells

Dominique Seppey

Muscular arteries are able to actively modify their diameter by modulating the tone of the smooth muscle cells located within the arterial wall. A small variation of lumen diameter has a large influence on blood flow as well as on arterial pressure. The ca ...

EPFL2009

Efficient oxygen transfer by surface aeration in shaken cylindrical containers for mammalian cell cultivation at volumetric scales up to 1,000 liters

Alfio Quarteroni, Florian Maria Wurm, David Hacker, Xiuwei Zhang, Nicola Parolini, Mathieu Benjamin Stettler, Marco Perrone, Dario De Sanctis

Cylindrical containers agitated by orbital shaking are being developed as simple and cost-effective bioreactor systems for the cultivation of mammalian cells. Here the oxygen transfer capacities of containers with nominal volumes from 50 mL to 2000 L were ...

2009

Orbitally shaken bioreactors for mammalian cell culture

Xiaowei Zhang

Driven by the commercial success of recombinant biopharmaceuticals, there is an increasing demand for novel, cost-effective mammalian cell culture bioreactor systems for the production of biologicals requiring mammalian protein processing. Recently, orbita ...

EPFL2009

N-removal optimization by various aeration strategies

Simon Taillard

In order to improve the purification capacity of an aerobic granular sludge, two aeration strategies were designed and tested. The goal was to optimize the nitrogen removal performances via various oxygen patterns in the aeration phase of the reactor cycle ...

2009

Glial Energy Metabolism: A NMR Spectroscopy Perspective

Rolf Gruetter

Oxygen metabolism is uniquely compartmentalized between neurons and glia, the latter comprising about 25% of neuronal energy metabolism. The consumption of acetate and fixation of CO2 in glutamine occur in astrocytes by oxygen-dependent reactions, which po ...

Elsevier2009

A structure-based model of arterial remodeling in response to sustained hypertension

Nikolaos Stergiopoulos, Alkiviadis Tsamis, Alexander Rachev

A novel structure-based mathematical model of arterial remodeling in response to a sustained increase in pressure is proposed. The model includes two major aspects of remodeling in a healthy matured vessel. First, the deviation of the wall stress and flow- ...

2009

Design and Optimization of a Lactate Amperometric Biosensor based on Lactate Oxidase and Multi Walled-Carbon Nanotubes

Giovanni De Micheli, Sandro Carrara, Cristina Boero

Lactate concentration in physiological fluids is an indicator of the energy production under anaerobic conditions of the whole organism [1]. Normal value for lactate level in blood ranges from 0.5 – 2.5 mM. Blood lactate values exceeding 7-8 mM are sometim ...

2008

High-sensitivity monitoring of micromechanical vibration using optical whispering gallery mode resonators

Tobias Kippenberg, Albert Schliesser

The inherent coupling of optical and mechanical modes in high finesse optical microresonators provides a natural, highly sensitive transduction mechanism for micromechanical vibration. Using homodyne and polarization spectroscopy techniques, we achieve sho ...

2008

Effects of dynamic compression on lentiviral transduction in an in vitro airway wall model

Melody Swartz, Alice Anna Tomei

Asthmatic patients are more susceptible to viral infection, and we asked whether dynamic strain on the airway wall (such as that associated with bronchoconstriction) would influence the rate of viral infection of the epithelial and subepithelial cells. To ...

2008

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