Récepteur (biochimie)

Johan Auwerx is Professor at the École Polytechnique Fédérale in Lausanne, Switzerland, where he occupies the Nestle Chair in Energy Metabolism. Dr. Auwerx has been using molecular physiology and systems genetics to understand metabolism in health, aging and disease. Much of his work focused on understanding how diet, exercise and hormones control metabolism through changing the expression of genes by altering the activity of transcription factors and their associated cofactors. His work was instrumental for the development of agonists of nuclear receptors - a particular class of transcription factors - into drugs, which now are used to treat high blood lipid levels, fatty liver, and type 2 diabetes. Dr. Auwerx was amongst the first to recognize that transcriptional cofactors, which fine-tune the activity of transcription factors, act as energy sensors/effectors that influence metabolic homeostasis. His research validated these cofactors as novel targets to treat metabolic diseases, and spurred the clinical use of natural compounds, such as resveratrol, as modulators of these cofactor pathways. Johan Auwerx was elected as a member of EMBO in 2003 and is the recipient of a dozen of international scientific prizes, including the Danone International Nutrition Award, the Oskar Minkowski Prize, and the Morgagni Gold Medal. His work is highly cited by his peers with a h-factor of over 100. He is an editorial board member of several journals, including Cell Metabolism, Molecular Systems Biology, The EMBO Journal, Journal of Cell Biology, Cell, and Science. Dr. Auwerx co-founded a handful of biotech companies, including Carex, PhytoDia, and most recently Mitobridge, and has served on several scientific advisory boards. Dr. Auwerx received both his MD and PhD in Molecular Endocrinology at the Katholieke Universiteit in Leuven, Belgium. He was a post-doctoral research fellow in the Departments of Medicine and Genetics of the University of Washington in Seattle.

Horst Vogel est né en 1948 à Würzburg, Allemagne. Après ses études en chimie, il obtient le diplôme de chimie en 1974 de l'Université de Würzburg.Il entreprend ensuite un travail de doctorat au Max-Planck Institut für Biophysikalische Chemie de Göttingen, et obtient en 1978 le grade de docteur ès sciences de l'Université de Göttingen. De 1978 à 1983 il effectue des recherches au Max-Planck Institut für Biologie à Tübingen et en 1984, il rejoint le Biocentre à Bâle où il travaille jusqu'en 1989, effectuant une année au Karolinska Institute à Stockholm. En 1989, Horst Vogel rejoint l'institut de chimie physique de l'EPFL où il dirige un groupe travaillant dans les domaines de la biophysique et de la bioélectronique. Depuis le 1er octobre 1994 il est profeseur en chimie physique des polymères et membranes au Département de chimie de EPFL. Ses intérêts de recherche sont l'étude de la structure et de la dynamique de récepteurs membranaires et l'auto-assemblage des biomolécules aux interfaces pour développer de nouveaux biocapteurs dans le domaine de micro- et nanotechnologie. Il enseigne les sciences du vivant, la biophysique et biochimie, et des chapitres concernant la biotechnologie. Dipl. in Chemistry1974-Univ. Würzburg, DE Ph.D.-1978-MPI für Biophys. Chemie, Göttingen, DE

Cathrin Brisken, MD, PhD, is Associate Professor of Life Sciences at the Swiss Federal Institute of Technology Lausanne (EPFL). Dr. Brisken is internationally recognized for her work on endocrine control of mammary gland development and breast carcinogenesis. Dr. Brisken received her MD and her PhD degree in Biophysics from the Georg August University of Göttingen, Germany. She completed her postdoctoral work in cancer biology with Dr. R.A. Weinberg at the Whitehead Institute of Biomedical Research in Cambridge, MA, USA. She previously held appointments at the Cancer Center of the Massachusetts General Hospital, Harvard Medical School, Boston and the Swiss Institute for Experimental Cancer Research (ISREC). Research in Dr. Brisken’s laboratory focuses on the cellular and molecular underpinnings of estrogen and progesterone receptor signaling in the breast and the respective roles of these hormones and hormonally active compounds in carcinogenesis. The aim is to understand how recurrent exposures to endogenous and exogenous hormones contribute to breast carcinogenesis in order to better prevent and treat the disease. The laboratory has pioneered in vivo approaches to genetically dissect the role of the reproductive hormones in driving mouse mammary gland development and shown how they control intercellular communication. Dr. Brisken’s group has developed ex vivo and humanized mouse models using patient samples to study hormone action in human tissues in normal settings and during disease progression. Dr. Brisken is member of the International Breast Cancer Study Group (IBCSG) Biological Protocol Working Group. She served as Dean of EPFL Doctoral School (more than 2000 PhD students in 18 PhD programs), as member of the Hinterzartener Kreis, the oncology think-tank associated with the German Science Foundation, and numerous Swiss, European, and AACR committees. She co-founded the International Cancer Prevention Institute.

Patrick Aebischer a achevé une formation en Médecine (1980) et en Neurosciences (1983) aux Universités de Genève et de Fribourg en Suisse. De 1984 à 1992, Patrick Aebischer a travaillé à Brown University (USA) au sein du Département des Neurosciences et au Département des Biomatériaux et des Organes Artificiels en tant que Professeur assistant, puis Professeur associé. En 1992, Patrick Aebischer a été nommé Professeur de la Division Autonome de Recherche Chirurgicale et du Centre de Thérapie Génique (DARC) au Centre Hospitalier Universitaire Vaudois (CHUV) à Lausanne. En 1999, Le Conseil Fédéral a nommé Patrick Aebischer en tant que Président de l'Ecole Polytechnique Fédérale de Lausanne (EPFL). Il a pris ses fonctions à la Présidence de l’EPFL en mars 2000, position qu'il a occupée jusqu'au 31 décembre 2016. Patrick Aebischer est membre de maintes sociétés professionnelles, tant en Europe qu’aux Etats-Unis. Patrick Aebischer a fondé trois start-up de biotechnologies. Il siège au conseil d'administration de Lonza, de Logitech et de Nestlé. Il préside également l'advisory board du Novartis Venture Fund. Patrick Aebischer est membre du conseil de fondation du Festival de Jazz de Montreux, du Festival de Verbier et de la Fondation Jacobs. Les recherches qu’il poursuit actuellement dans son laboratoire se concentrent sur le développement d'approches de thérapie cellulaire et de transfert génique pour le traitement des maladies neurodégénératives.

URS VON GUNTEN born in Baden (Switzerland) on 20/10/1959 RESEARCH INTERESTS Drinking water quality and water treatment. Unit processes and process combinations (adsorption processes, membrane processes, oxidation processes). Chemical oxidation and advanced oxidation processes: kinetics and mechanisms of formation of disinfection by-products and degradation of micropollutants. Assessment of toxicology of of transformation products. Biogeochemical processes in riverbank filtration systems. In situ and out-of-ground treatment of groundwaters EDUCATION Diploma Swiss Federal Institute of Technology (ETH) Zürich, Department of Chemistry,Switzerland, 1983 Ph.D.Swiss Federal Institute of Technology (ETH) Zürich, Switzerland, 1989. AWARDS AND FELLOWSHIPS 2018 Clarivate Analytics Highly Cited Researcher 2015 Thomson Reuters Highly Cited Researcher 2015 Recipient of the Harvey Rosen Award 2015 of the International Ozone Association 2015 Professorship under the Chinese Academy of Sciences President’s International Fellowship Initiative for Distinguished Scientists 2014 Thomson Reuters Highly Cited Researcher 2013 Distinguished Lecturer for AEESP at the American Water Works Association Annual Conference, Denver, June 10, 2013 2012-to date Adjunct Professor at the Gwangju Institute of Science and Technology, Korea 2011 Full Professor at the Swiss Federal Institute of Technology, Lausanne (EPFL) 2010 Adjunct Professor at the State Key Laboratory of Environmental Aquatic Chemistry, Chinese Academy of Sciences 2010 Adjunct Professor at the Curtin University of Technology, Perth, Australia 2007 Honorary Professorship at the Harbin Institute of Technology, Harbin, China 2007 Recipient of the Harvey Rosen Award 2007 of the International Ozone Association 2007 Environmental Science and Technology Excellence in Review Award 2006 Professor title at ETHZ, Department of Environmental Sciences 2001 Recipient of the Harvey Rosen Award 2001 of the International Ozone Association 1999 Recipient of the Marteen Schalekamp Award 1999 of the IWSA 1993 Recipient of a short-term fellowship of the Swiss National Science Foundation in 1993 and 1994 1993 EERO short-term fellowship-holder PROFESSIONAL RECORD 2013-2016 Head of transdisciplinary project “Regional Water Supply Basel Country 21”, Eawag 2010-2017 Head of Competence Center for Drinking Water, Eawag 2008/2009 Visiting Professor at the Curtin Water Quality Research Centre, Curtin University of Technology, Perth, Australia 2004-to date Deputy head of department ”Water Resources and Drinking Water”, Eawag 2004-2008 Head of the cross-cutting project “Drinking water for the 21st century”, Eawag 2000 – 2004 Head of department ”Water Resources and Drinking Water”, Eawag 2000/2001 Sabbatical at University of Colorado, Boulder 1998 - 1999 Head of department of Chemistry, Eawag 1995 - 2011 Lecturer at Swiss Federal Institute of Technology (ETH) Zürich, Switzerland. 1995- to date Group leader of the drinking water group of the chemistry department at Eawag 1994/93 Visiting Scientist at the International Research Center for Water and Environment of Lyonnaise des Eaux (8 months), CIRSEE, Le Pecq, France since 1992 Research Scientist at Eawag 1989 - 1991 Postdoctoral Researcher at Eawag 1984 - 1989 Research Assistant, Swiss Federal Institute of Technology, Zürich EDITORIAL ACTIVITIES Associate Editor “Environmental Science and Technology” (2010/2011) Guest Editor “Water Research” for special issue on “Emerging Contaminants” (2010) Guest Editor „Journal of water supply: Research and Technology-Aqua“ for a special issue on “Oxidation Processes” (2008) Member of the editorial board of the journal ”Ozone: Science and Engineering”. Member of the editorial board of „Journal of water supply: Research and Technology-Aqua“. FORMER PROFESSIONAL ACTIVITIES 2016 Co-organizer of PEAK seminar ”Neue Herausforderungen und Lösungsansätze in der Wasserversorgung – Fallbeispiele aus dem Kanton BL”. Dübendorf, November 11, 2016 2015 Organizer of PEAK seminar “Micropollutants in drinking water”, Dübendorf, October 30 2014 Co-organizer of the Eawag Infotag “Wasserversorgung und Uferfiltration – ein System unter Druck?” Dübendorf, September 9, 2014 2014 Co-organizer of a Symposium “Advanced oxidation processes for water treatment” 5th EuCheMS Chemistry Congress 2014, Aug. 31 – Sept. 4, Istanbul, Turkey, 2014 2013 Co-Organizer of PEAK seminar on “Oxidation and Disinfection Processes”, Aug. 30, Dübendorf 2013 Co-Organizer of the Micropoll & Ecohazard Conference, Zürich, June 17-19, 2013 2013 Co-Organizer of the session “Advanced Oxidation – Technologies and Applications, Leading Edge Technology (LET) Conference, Bordeaux, June 2-6, 2013 2011 Co-Organizer of Korean-Swiss Science Days in Zürich “Water for the Future”, ETHZ, November 9-10, 2011. 2010 Co-Organizer of an international symposium “Oxidation processes in natural and technical aquatic systems” in honour of Jürg Hoigné’s 80 birthday, Eawag, May 21, 2010. 2010 Co-Organizer of 23. Mülheimer Wassertechnisches Seminar “Möglichkeiten und Grenzen von oxidativen Prozessen in der Wasserreinhaltung”, March 11, 2010, IWW, Mülheim an der Ruhr 2008 Co-Organizer of the Eawag Infotag 2008 “Vom Gewässer ins Glas”, Sept. 12, 2008, Eawag, Dübendorf 2008 Organizing committee of Leading Edge Technology Conference (LET), Zürich, June 1-4, 2008. 2008 Co-organizer of Sino-Swiss workshop “Water Resources Management and Drinking Water Quality”, Harbin Institute of Technology, Harbin, China, January, 2008 2007 Organizer of Wave21 seminar on “New insights in the field of drinking water treatment”, Dübendorf, Sept. 14, 2007. 2007 Co-organizer of a symposium entitled “Sustainability in Water Supply: Advances in Oxidation Processes for Water Treatment” at ACS Spring conference, Chicago, March 25-29, 2007. 2006 Organizer of Wave21 seminar on “New developments of analytical methods for drinking water analysis”, Dübendorf, Sept. 15, 2006, 2005 Organizer of Wave21 seminar on “New applications of ozone in water treatment”, Sept. 23, 2005, Dübendorf 1999 Co-organizer of 200th Anniversary Symposium in honor of Ch. F. Schönbein - the discoverer of ozone, October 1999, Basel. 1995 Organizer of a symposium in honor of J. Hoigné, June, 1995, Dübendorf, Switzerland 1991 Co-organizer of the workshop "Chemodynamics of Groundwaters", November, 1991, Mont Sainte-Odile, France