Pedro Miguel Nunes Pereira de Almeida ReisPedro M. Reis is a Professor of Mechanical Engineering at the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, where he is the Director of the Institute of Mechanical Engineering. Prof. Reis received a B.Sc. in Physics from the University of Manchester, UK (1999), a Certificate of Advanced Studies in Mathematics (Part III Maths) from St. John’s College and DAMTP, University of Cambridge (2000), and a Ph.D. in physics from the University of Manchester (2004). He was a postdoc at the City College of New York (2004-2005) and at the CNRS/ESPCI in Paris (2005-2007). He joined MIT in 2007 as an Instructor in Applied Mathematics. In 2010 he moved to MIT’s School of Engineering, with dual appointments in Mechanical Engineering and Civil & Environmental Engineering, first as the Esther and Harold E. Edgerton Assistant Professor and, since the summer of 2014 as Gilbert W. Winslow Associate Professor. In October 2013, the Popular Science magazine named Prof. Reis to its 2013 “Brilliant 10” list of young stars in Science and Technology. He has received the 2014 CAREER Award (NSF), the 2016 Thomas J.R. Hughes Young Investigator Award (Applied Mechanics Division of the ASME), the 2016 GSOFT Early Career Award for Soft Matter Research (APS), he is a Fellow of the APS, and he is the 2021 President of the Society of Engineering Science (SES).
Daniel FavratDaniel Favrat a obtenu à l'EPFL son diplôme d'ingénieur mécanicien en 1972 et le titre de docteur ès sciences techniques en 1976.
Il passe ensuite 12 ans dans des centres de recherche industriels au Canada et en Suisse.Depuis 1988, D. Favrat est professeur et directeur du Laboratoire d'énergétique industrielle à l'EPFL. Il est aussi successivement directeur de l'Institut des Sciences de l'énergie et, dès janvier 2007, de l'Institut de Génie Mécanique. Ses recherches portent sur les analyses systémiques prenant en compte l'énergétique, l'environnement et l'économie (optimisation environomique), et les systèmes avancés pour une utilisation plus rationnelle de l'énergie (pompes à chaleur, moteurs, piles à combustible,turbomachines etc.)
Il est membre de l'Académie Suisse des Sciences Techniques et vice-président du comité énergie de la Fédération Mondiale des Organisations d'Ingénieurs. Il est éditeur associé du journal "Energy" et l'auteur de deux livres sur la thermodynamique et l'énergétique publiés aux Presses Polytechniques Universitaires Romandes.
David Atienza AlonsoDavid Atienza Alonso is an associate professor of EE and director of the Embedded Systems Laboratory (ESL) at EPFL, Switzerland. He received his MSc and PhD degrees in computer science and engineering from UCM, Spain, and IMEC, Belgium, in 2001 and 2005, respectively. His research interests include system-level design methodologies for multi-processor system-on-chip (MPSoC) servers and edge AI architectures. Dr. Atienza has co-authored more than 350 papers, one book, and 12 patents in these previous areas. He has also received several recognitions and award, among them, the ICCAD 10-Year Retrospective Most Influential Paper Award in 2020, Design Automation Conference (DAC) Under-40 Innovators Award in 2018, the IEEE TCCPS Mid-Career Award in 2018, an ERC Consolidator Grant in 2016, the IEEE CEDA Early Career Award in 2013, the ACM SIGDA Outstanding New Faculty Award in 2012, and a Faculty Award from Sun Labs at Oracle in 2011. He has also earned two best paper awards at the VLSI-SoC 2009 and CST-HPCS 2012 conference, and five best paper award nominations at the DAC 2013, DATE 2013, WEHA-HPCS 2010, ICCAD 2006, and DAC 2004 conferences. He serves or has served as associate editor of IEEE Trans. on Computers (TC), IEEE Design & Test of Computers (D&T), IEEE Trans. on CAD (T-CAD), IEEE Transactions on Sustainable Computing (T-SUSC), and Elsevier Integration. He was the Technical Program Chair of DATE 2015 and General Chair of DATE 2017. He served as President of IEEE CEDA in the period 2018-2019 and was GOLD member of the Board of Governors of IEEE CASS from 2010 to 2012. He is a Distinguished Member of ACM and an IEEE Fellow.
Jacques FellayJacques Fellay is a medical scientist with expertise in infectious diseases and human genomics. He obtained his MD from the University of Lausanne in 2002 and his PhD from University of Utrecht. After a clinical training in infectious diseases in Switzerland and a 4-years postdoctoral fellowship at Duke University, he joined the EPFL in April 2011 with an SNF Professorship.
On top of his EPFL affiliation, Jacques is also Head of Precision Medicine at the University Hospital (CHUV) in Lausanne, Group Leader at the Swiss Institute of Bioinformatics, and Co-director of the Health2030 Genome Center at Campus Biotech in Geneva.
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Bryan German Pantoja RoseroSince 2020 Doctoral Assistant at EPFL2016 - 2018 M.Sc. in Structures and Civil Construction, University of Brasilia, Brazil2014 - 2015 Specialist in Roads and Transport, National University of Colombia, Colombia 2009 - 2014 B.Sc. in Civil Engineering, National University of Colombia, Colombia
Jean-Philippe AnsermetJean-Philippe Ansermet was born March 1, 1957 in Lausanne (legal origin Vaumarcus, NE). He obtained a diploma as physics engineer of EPFL in 1980. He went on to get a PhD from the University of Illinois at Urbana-Champaign where, from 1985 to 1987, he persued as post-doc with Prof. Slichter his research on catalysis by solid state NMR studies of molecules bound to the surface of catalysts. From 1987 to 1992 he worked at the materials research center of Ciba-Geigy, on polymers for microelectronics, composites, dielectrics and organic charge transfer complexes. In March 1992, as professor of experimental physics, he developed a laboratory on the theme of nanostructured materials and turned full professor in 1995. Since 1992, he teaches classical mechanics, first to future engineering students, since 2004 to physics majors. Since 2000, he teaches thermodynamics also, to the same group of students. He offers a graduate course in spintronics, and another on spin dynamics. His research activities concern the fabrication and properties of magnetic nanostructures produced by electrodeposition. His involvement since the early days of spintronics have allowed him to gain recognition for his work on giant magnetoresistance (CPP-GMR), magnetic relaxation of single nanostructures, and was among the leading groups demonstrating magnetization reversal by spin-polarized currents. Furthermore, his group uses nuclear magnetic resonance , on the one hand as means of investigation of surfaces and electrodes, on the other hand, as a local probe of the electronic properties of complex ferromagnetic oxides.
