Dominique BonvinDominique Bonvin is Professor and Director of the Automatic Control Laboratory of EPFL. He received his Diploma in Chemical Engineering from ETH Zürich, and his Ph.D. degree from the University of California, Santa Barbara. He worked in the field of process control for the Sandoz Corporation in Basel and with the Systems Engineering Group of ETH Zürich. He joined the EPFL in 1989, where his current research interests include modeling, control and optimization of dynamic systems. He served as Director of the Automatic Control Laboratory for the periods 1993-97, 2003-2007 and again since 2012, Head of the Mechanical Engineering Department in 1995-97 and Dean of Bachelor and Master Studies at EPFL for the period 2004-2011.
Wulfram GerstnerWulfram Gerstner is Director of the Laboratory of Computational Neuroscience LCN at the EPFL. His research in computational neuroscience concentrates on models of spiking neurons and spike-timing dependent plasticity, on the problem of neuronal coding in single neurons and populations, as well as on the link between biologically plausible learning rules and behavioral manifestations of learning. He teaches courses for Physicists, Computer Scientists, Mathematicians, and Life Scientists at the EPFL. After studies of Physics in Tübingen and at the Ludwig-Maximilians-University Munich (Master 1989), Wulfram Gerstner spent a year as a visiting researcher in Berkeley. He received his PhD in theoretical physics from the Technical University Munich in 1993 with a thesis on associative memory and dynamics in networks of spiking neurons. After short postdoctoral stays at Brandeis University and the Technical University of Munich, he joined the EPFL in 1996 as assistant professor. Promoted to Associate Professor with tenure in February 2001, he is since August 2006 a full professor with double appointment in the School of Computer and Communication Sciences and the School of Life Sciences. Wulfram Gerstner has been invited speaker at numerous international conferences and workshops. He has served on the editorial board of the Journal of Neuroscience, Network: Computation in Neural Systems', Journal of Computational Neuroscience', and `Science'.
Lyesse LalouiDirector, EPFL Soil Mechanics LaboratoryDirector, EPFL Civil Engineering SectionEditor in Chief, ElsevierMember of the Swiss Academy of Engineering SciencesFounding Partner, Geoeg & MeduSoilActive in academic research in the following institutions: Lausanne, EPFL, Durham, Duke University, Nanjing, Hohai UniversityProfessor Lyesse Laloui teaches at EPFL, where he directs the Soil Mechanics Laboratory as well as the Civil Engineering Section. He is a founding partner of the international engineering company Geoeg, and the start-up MeduSoil. In addition, he is an adjunct professor at Duke University, USA and an advisory professor at Hohai University, China as well as honorary director of the International Joint Research Center for Energy Geotechnics in China.He is the recipient of an Advance ERC grant for his BIO-mediated GEO-material Strengthening project. Editor in Chief of the Elsevier Geomechanics for Energy and the Environment journal, he is a leading scientist in the field of geomechanics and geo-energy. He has written and edited 13 books and published over 320 peer reviewed papers; his work is cited more than 6000 times with an h-index of 39 (Scopus). Two of his papers are among the top 1% in the academic field of Engineering. He has given keynote and invited lectures at more than 40 leading international conferences. He has received several international awards (IACMAG, RM Quigley, Roberval) and delivered honorary lectures (Vardoulakis, Minnesota; G.A. Leonards, Purdue; Kersten, Minnesota). He recently acted as the Chair of the international evaluation panel of Civil and Geological Engineering R&D Units of Portugal.Nov. 2019 For further information visit www.epfl.ch/labs/lms/ ; geoeg.net ; medusoil.com Ian SmithPhD Université de Cambridge, 1982 Interêts 1 Contrôle actif de la forme des structures pour améliorer leur aptitude au service et leur déploiement 2 Structures biomimétiques (apprentissage, auto-diagnostic, auto-réparation) 3 Gestion de l'infrastructure par l'identification structurale 4 Applications avancées de l'informatique Plus de détails, voir https://www.epfl.ch/labs/imac/fr/recherche/smith_ian_fr/ Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Roger HerschRoger D. Hersch is professor of Computer Science and head of the Peripheral Systems Laboratory at EPFL. He received his engineering degree from ETHZ in 1975, worked in industry from 1975 to 1980, and obtained his PhD degree from EPFL in 1985. He directed the widely known
Visible Human Web Server project
, which offers a number of services for the visualization of human anatomy.
His current research focuses on color reproduction, spectral color prediction models, moiré imaging, and visual document security. Recent achievements include the PhotoProtect technology, which incorporates text as chromatic differences in order to protect identity photographs (Swiss driving license), microstructure imaging, which is used by railways companies (SNCF, RENFE) and festival organizers (Paleo) to print tickets at home and the band moire imaging technology for the protection of security documents.
