Anton SchleissProf. Dr. Anton J. Schleiss graduated in Civil Engineering from the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland, in 1978. After joining the Laboratory of Hydraulic, Hydrology and Glaciology at ETH as a research associate and senior assistant, he obtained a Doctorate of Technical Sciences on the topic of pressure tunnel design in 1986. After that he worked for 11 years for Electrowatt Engineering Ltd. (now Pöyry) in Zurich and was involved in the design of many hydropower projects around the world as an expert on hydraulic engineering and underground waterways. Until 1996 he was Head of the Hydraulic Structures Section in the Hydropower Department at Electrowatt. In 1997, he was nominated full professor and became Director of the Laboratory of Hydraulic Constructions (LCH) in the Civil Engineering Department of the Swiss Federal Institute of Technology Lausanne (EPFL). The LCH activities comprise education, research and services in the field of both fundamental and applied hydraulics and design of hydraulic structures and schemes. The research focuses on the interaction between water, sediment-rock, air and hydraulic structures as well as associated environmental issues and involves both numerical and physical modeling of water infrastructures. In May 2018, he became Honorary Professor at EPFL. More than 50 PhD and Postdoc research projects have been carried out under his guidance. From 1999 to 2009 he was Director of the Master of Advanced Studies (MAS) in Water Resources Management and Hydraulic Engineering held in Lausanne in collaboration with ETH Zurich and the universities of Innsbruck (Austria), Munich (Germany), Grenoble (France) and Liège (Belgium). From 2006 to 2012 he was the Head of the Civil Engineering program of EPFL and chairman of the Swiss Committee on Dams (SwissCOLD). In 2006, he obtained the ASCE Karl Emil Hilgard Hydraulic Price as well as the J. C. Stevens Award. He was listed in 2011 among the 20 international personalities that “have made the biggest difference to the sector Water Power & Dam Construction over the last 10 years”. Between 2014 and 2017 he was Council member of International Association for Hydro-Environment Engineering and Research (IAHR) and he was chair of the Europe Regional Division of IAHR until 2016. For his outstanding contributions to advance the art and science of hydraulic structures engineering he obtained in 2015 the ASCE-EWRI Hydraulic Structures Medal. The French Hydro Society (SHF) awarded him with the Grand Prix SHF 2018. After having served as vice-president between 2012 and 2015 he was president of the International Commission on Large Dams (ICOLD) from 2015 to 2018. On behalf of ICOLD he his the coordinator of the EU Horizon 2020 project "Hydropower Europe". With more than 40 years of experience he is regularly involved as a consultant and expert in large water infrastructures projects including hydropower and dams all over the world. Awards (besides those mentioned above): ASCE-Journal of Hydraulic Engineering Outstanding Reviewer Recognition 2013 ASCE-EWRI-Journal of Hydraulic Engineering 2014 Best Technical Note
Yann BarrandonYann Barrandon graduated in Medicine in Paris where he also trained as a dermatologist and completed his PhD on the long term cultivation of human haematopoietic stem cells in 1982 under the direction of Dr. Catherine Dresch (Centre Hayem, St Louis Hospital). He worked as a post-doctoral fellow (1982-1983) with Pr. Marvin Karasek in the Department of Dermatology at Stanford University CA, and then with Pr. Howard Green, a pioneer in cell therapy, in the Department of Molecular and Cellular Physiology at Harvard Medical School (1983-1990). During this period, he participated in the world's first transplantations of epidermal stem cells on extensive third degree wounds and contributed several seminal findings including the demonstration of stem cells in cultures of human keratinocytes (PNAS 1987), and that human keratinocyte stem cells could be efficiently transduced by retroviral vectors (Science 1987), in collaboration with Richard Mulligan at the Whitehead Institute for Biomedical Research (Massachussets Institute of Technology, Cambridge, USA). He has also participated to the transfer of the stem cell technology from Harvard University to a spin off biotechnology company, now part of Genzyme Corp.
He returned to France in 1990 as Director of Research at the INSERM and Head of Lab at the Ecole Normale Supérieure, Paris. During this period, he demonstrated the presence of multipotent clonogenic stem cells in hair follicles (Cell 1994, 2001) and successfully brought stem cells from bench to bedside demonstrating the usefulness of a fibrin matrix to transplant epidermal stem cells. (Transplantation, 2000). Following his move to Lausanne, Yann Barrandon has shown that oligopotent stem cells are present in the mammalian cornea (Nature 2008), challenging previous dogma. He has also contributed to the characterisation of several skin diseases (Nature Genetics, 1993a, 1993b, 2000, 2005) and towards gene therapy of dystrophic epidermolysis bullosa. He is a partner in several EEC stem cell consortia (FP6: Therapeuskin and EuroStemCell, FP7: EuroSyStem, OptiStem, BetaCellTherapy).
Current research targets the role of small microenvironmental variations on stem cell behavior, and exploring the potency of stem cells of stratified epithelia (skin, esophagus, ocular surface) and of thymic epithelial cells. The lab is also involved in understanding the factors that regulate stem cell engraftment to improve epithelial cell therapy. An important aspect of the research aims at setting up a pilot clinical trial to demonstrate the feasibility of ex vivo gene therapy to treat Dystrophic Epidermolysis Bullosa, a rare but horrendous congenital disease of the skin that results in continuous blistering of the skin, chronic wounds, fusion of fingers and development of carcinoma.
Yann Barrandon was a member of the Faculty Council of the EPFL School of Life Sciences 2006-2008, of the Board of Swiss Stem Cell Network, 2004-2009, and is a member of the EPFL Ethics Committee since 2008. He is a reviewer for major scientific journals and for major granting agencies abroad. He is a member of the board of Directors of the International Society for Differentiation (ISD) and of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and was a Member of the Board of Directors of the European Tissue Repair Society, 1990-1995. He was elected as EMBO member in 2009.
He has given over 300 invited conferences and seminars worldwide on the biology and the therapeutic use of cutaneous stem cells including:
Gordon Research Conferences, Tissue Repair and Regeneration, June 2005, New London, USA,
Keystone Symposia on Stem Cells, April 2006, Whistler, Canada
Keystone Symposia, Stem Cell Interactions with their Microenvironmental Niche, March 2007, Keystone, USA
Keystone Symposia, Stem Cell Niche Interactions, April 2009, Whistler, Canada
Gordon Research Conferences, Epithelial Stem Cells, June 2009, Les Diablerets, Switzerland
7th Meeting of the International Society Stem Cell Research, July 2009, Barcelona, Spain
16th International Society for Developmental Biologists, Edinburgh, Scotland, UK, Sept 2009
Yann Barrandon has given multiple media interviews and participated to different reportages:
LCI, TF1, France 2, France 3, RSR (Radio Suisse Romande), TSR (Television Suisse Romande), and articles in newspapers: Figaro, La Croix, Le Temps, LHebdo, Le Nouvelliste, etc. He was also a participant in the movie A Stem Cell Story, EuroStemCell, Best TV/video production, Tromsø Science Media Festival; Best short film, Scinema (Australia); In competition, Science Film Festival (Bangkok), BaKaFORUM 2007, Vedere la Scienza
He organized the second EuroStemCell international conference Advances in Stem Cell Research supported by the EMBO and held in Lausanne 8-10 September 2006. He regularly participates as faculty to the EEC funded Stem Cell Summer School held in Hydra Greece since 2005.
