Concept
Prolactinome
Publications associées (7)
Functional consequences of prolactin signaling in endothelial cells: a potential link with angiogenesis in pathophysiology?
Prolactin is best known as the polypeptide anterior pituitary hormone, which regulates the development of the mammary gland. However, it became clear over the last decade that prolactin contributes to a broad range of pathologies, including breast cancer. ...
2012Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation
PTEN acts as a tumor suppressor in a range of tissue types and has been implicated in the regulation of intestinal stem cells. To study Pten function in the intestine, we used various conditional transgenic strategies to specifically delete Pten from the m ...
2008Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function
Prolactin is an ancient hormone, with different functions in many species. The binding of prolactin to its receptor, a member of the cytokine receptor superfamily, results in the activation of different intracellular signaling pathways, such as JAK2/STAT5, ...
2003IGF-2 is a mediator of prolactin-induced morphogenesis in the breast
The mechanisms by which prolactin controls proliferation of mammary epithelial cells (MECs) and morphogenesis of the breast epithelium are poorly understood. We show that cyclin D1(-/-) MECs fail to proliferate in response to prolactin and identify IGF-2 a ...
2002