Concept

Astrocyte

Publications associées (285)

Astrocytic beta(2)-adrenergic receptors mediate hippocampal long-term memory consolidation

Pierre Magistretti, Sylvain Eric Lengacher, Virginia Gao

Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic recepto ...

National Academy of Sciences2016

Glycosphingolipid–Protein Interaction in Signal Transduction

Glycosphingolipids (GSLs) are a class of ceramide-based glycolipids essential for embryo development in mammals. The synthesis of specific GSLs depends on the expression of distinctive sets of GSL synthesizing enzymes that is tightly regulated during devel ...

2016

Proteolytic processing of the synaptic cell adhesion molecule neurexin-3beta and the neurobiological functions of the resulting cleavage products

Magda Maria Palczynska

Neurexins are key synaptic cell adhesion molecules involved in synapse specification and maturation. They couple synaptic activity and cell adhesion to regulate activity-dependent synapse development. Recently, neurexin processing by alpha- and gamma- secr ...

EPFL2016

Presurgical brain mapping in epilepsy using simultaneous EEG and functional MRI at ultra-high field: feasibility and first results

Wietske Van der Zwaag, João Pedro Forjaco Jorge, François Lazeyras, Giannina Rita Iannotti

OBJECTIVES: The aim of this study was to demonstrate that eloquent cortex and epileptic-related hemodynamic changes can be safely and reliably detected using simultaneous electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) recordings ...

Springer Verlag2016

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

Pierre Magistretti, Patrick Aebischer, Bernard Schneider, Sylvain Eric Lengacher

Excitatory synaptic transmission is accompanied by a local surge in interstitial lactate that occurs despite adequate oxygen availability, a puzzling phenomenon termed aerobic glycolysis. In addition to its role as an energy substrate, recent studies have ...

Society for Neuroscience2015

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution

Rolf Gruetter

Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Glutamate, the major excitatory neurotransmitter, is foreseen as a complementary energy contributor in the brain. In particular, astrocytes actively take up glut ...

Elsevier2015

A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue

Pierre Magistretti, Maha Elsayed

Mental illnesses have long been perceived as the exclusive consequence of abnormalities in neuronal functioning. Until recently, the role of glial cells in the pathophysiology of mental diseases has largely been overlooked. However recently, multiple lines ...

Frontiers Media Sa2015

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron-Astrocyte Metabolic Coupling in Long Term Memory

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Sylvain Eric Lengacher, Monika Tadi

We examined the expression of genes related to brain energy metabolism and particularly those encoding glia (astrocyte)-specific functions in the dorsal hippocampus subsequent to learning. Context-dependent avoidance behavior was tested in mice using the s ...

Public Library of Science2015

Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble

Pierre Magistretti, Igor Allaman, Jay Coggan, Renaud Jolivet

Glucose is the main energy substrate in the adult brain under normal conditions. Accumulating evidence, however, indicates that lactate produced in astrocytes (a type of glial cell) can also fuel neuronal activity. The quantitative aspects of this so-calle ...

Public Library of Science2015

Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation

Elizabeth Anne Allen

Guidepost cells present at and surrounding the midline provide guidance cues that orient the growing axons through commissures. Here we show that the transcription factor Nkx2.1 known to control the specification of GABAergic interneurons also regulates th ...

Nature Publishing Group2015

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